Safety of Human Embryonic Stem Cell (hESC)-Derived Mesenchymal Stem Cells in Interstitial Cystitis

Inclusion Criteria: * Female, aged \>= 20 years * Interstitial cystitis symptom duration more than 6 months * Presence of Hunner lesions in outpatient cystoscopy (within one months of screening), with size \< 2cm, number \<= 2 * VAS (Visual pain analogue scale) \>=4 in screening symptom questionnaire * Those who are suitable for stem cell transplantation * normal laboratory findings (hematological, chemical) * no history of drug abuse * negative HIV, HBV, HCV serology tests * No history of malignancies * willing to contraception * no plan for blood, tissue donation * Who can understand consent form and willing to participate in the study Exclusion Criteria: * recurrent urinary tract infection ( more than twice per past six months or more than three times per past one year) or active urinary tract infection * any active or past history of tuberculosis or systemic infection * Anatomical abnormality of lower urinary tract * History of following procedures * stem cell transplantation In past 6 months, * transurethral resection/fulguration of Hunner lesion or hydrodistension of bladder * intravesical instillation of ialuril * hysterectomy, anti-incontinence surgery, transvaginal surgery, pelvic organ prolapse repair, vagina delivery or C/sec * any neurological conditions including cerebrovascular disease, multiple sclerosis, spinal cord injury, Parkinson disease * indwelling Foley catheter or intermittent catheterization * any plans for electrostimulation, neuromodulation, physiotherapy or operation for other organs * any history of malignancy * history of myocardiac infarction in past 12 months * Uncontrolled diabetes (HbAlc \>= 7.2%) or diabetes requiring insulin injection * Uncontrolled hypertension (systolic \>170mmHg or \<90mmHg, diastolic \>100mmHg or \<50mmHg) * Immunodeficiency * Positive HBV, HCV, HIV, syphilis * pregnant or on breast feeding * any history of drug, alcohol abuse. mis-use * Any significant signs, symptoms or previous diagnosis of psychological disorder * Impossible to follow scheduled visits * Currently participating or participated in other clinical studies within past 3 months * Allergic to protein products (serum), antibiotics (gentamicin), DMSO (Dimethyl sulfoxide) * Any circumstances that is not suitable for participating or continuing clinical study or participants who clinical investigator considers not suitable for participation