OC and ICTP in Gingival Crevicular Fluid During Piezocision Accelerated Orthodontic Treatment

N/ACompletedNCT04611984

Marmara University15 enrolled

Overview

The aim of this study was to evaluate the tooth movement with and without piezocision with regard to the levels of osteocalcin and cross-linked C-terminal telopeptides of type I collagen in the gingival crevicular fluid.

15 systemically healthy subjects requiring extraction of the maxillary 1. premolars with distalization of the maxillary canines were enrolled to the study. Piezocisions were performed on the distal and mesial sides of the right maxillary canines while the left maxillary canines served as controls. Canine distalization was performed via closed-coil springs applying 150 g of force per side by using miniscrews as anchorage. Gingival crevicular fluid samples were collected from both mesial and distal sides of right and left maxillary canines at 0, 1, 7, 14 and 28 days. The gingival crevicular fluid levels of osteocalcin and cross-linked C-terminal telopeptides of type I collagen were determined by using ELISA. The rate of tooth movement was measured on 14 and 28 days.

Study Type

INTERVENTIONAL

Allocation

NON_RANDOMIZED

Purpose

TREATMENT

Masking

DOUBLE

Enrollment

Conditions

Tooth Movement

Interventions

PiezocisionPROCEDURE

Piezocisions were performed on the mesial and distal sides of the right maxillary canines. Then canine distalization was performed via closed-coil springs applying 150 g of force by using mini-screws as anchorage.

ControlPROCEDURE

The mesial and distal sides of the left maxillary canines served as controls and canine distalization was performed via closed-coil springs applying 150 g of force by using mini-screws as anchorage.

Eligibility

Sex: ALLMin age: 13 YearsMax age: 20 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Class I, Class II or Class III malocclusion, * Proclined incisors requiring extraction of the maxillary first premolars with subsequent retraction of the maxillary canines * No previous orthodontic treatment * Good oral hygiene and periodontal health (plaque and gingival indices less or equal 1, probing depth less or equal 3 mm, no radiographic bone loss). Exclusion Criteria: * having systemic diseases that could affect bone and tooth movement * smoking

Locations (1)

Marmara University Faculty of Dentistry

Istanbul, Turkey (Türkiye)

Outcomes

Primary Outcomes

Gingival crevicular fluid osteocalcin level (ng/ml)

Gingival crevicular fluid samples were collected from mesial and distal sides of the maxillary right and left canines.The gingival crevicular fluid level of osteocalcin was determined by using ELISA

Time frame: 28 days after canine distalization

Gingival crevicular fluid cross-linked C-terminal telopeptides of type I level (ng/ml)

Gingival crevicular fluid samples were collected from mesial and distal sides of the maxillary right and left canines.The gingival crevicular fluid level of cross-linked C-terminal telopeptides of type I collagen was determined by using ELISA.

Time frame: 28 days after canine distalization

Secondary Outcomes

The amount of canine movement (mm)

All measurements were performed on the dental cast model using a digital caliper. The amount of space closure was based on the measurements of the distance between the contact points of the distal surface of canine and the mesial surface of second premolar. The change of distance between the three observation periods represented the amount of canine movement.

Time frame: Baseline (day 0) before canine distalization and, 14 and 28 days after canine distalization

Retraction rate (mm/day) of canine movement

Time frame: 14 and 28 days after canine distalization

Data from ClinicalTrials.gov

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