An Amniotic Membrane Injection Comparing Two Doses (1 mL and 2 mL Injection) and a Placebo (Sterile Saline) in the Treatment of Osteoarthritis of the Knee

Inclusion Criteria: * Patient is a candidate for non-surgical intervention of the knee * Patient must be between the ages of 21 and 80 years old * Patient must have a diagnosis of osteoarthritis (OA) of the knee defined as grade 1 to 3 on the Kellgren-Lawrence grading scale Exclusion Criteria: * Patient has a diagnosis of osteoarthritis with a Kellgren-Lawrence grade of 4 * Patient has a BMI greater than 40 kg/m2, active infection at the injection site, symptomatic OA of the contralateral knee or of either hip that is not responsive to acetaminophen (Tylenol) and requires other therapy * Patient has rheumatoid arthritis, psoriatic arthritis or diagnosis with any other disorder that is the primary source of their knee pain * Patient has an autoimmune disease or known history of having Acquired Immunodeficiency Syndrome (AIDS) or HIV * Patient has any of the following treatments to the target knee within 12 weeks prior to screening * Intra-articular hyaluronic acid (HA) injection * Steroid or platelet rich plasma (PRP) injection * Use of any investigational drug, device, or biologic * Patient had or is planning to have major surgery or arthroscopy in the target knee within 26 weeks of treatment * Patient has a history of partial or total knee arthroplasty * Patient has undergone immunotherapy or chemotherapy in the last 5 years, prior radiation at the site, or is currently taking a narcotic medication for any reason * Patient is pregnant or plans to become pregnant within 365 days of treatment * Patient has any significant medical condition that would interfere with protocol evaluation and participation * Patient is a recipient of worker's compensation * Patient is a current prisoner