The EMINENCE Study - PET/MR Imaging of Head Neck Cancer

Inclusion Criteria: * willing and able to give full written consent according to the protocol approved by the Regional Ethics Committee * histologically confirmed squamous cell carcinoma in the head neck region (pharynx, larynx, oral cavity or sinonasal area) * locally advanced disease without sign of dissemination (T3/T4 and/or N1-3, M0) on diagnostic imaging * scheduled for definitive radiotherapy with curative intent with or without concomitant chemotherapy * adequate renal function: Creatinine clearance ≥ 60 ml/minute * lymph node metastasis from cancer of unknown primary of the upper neck (i.e. level II-III) were PET/CT is negative outside the head-neck region can be considered for inclusion at the discretion of the study investigators. Exclusion Criteria: * general contraindications for MRI (pacemaker, aneurysm clips, any form of metal in the body, severe claustrophobia) * serious comorbidity (including previous or othe cancer) that in the opinion of the investigator would compromise the patient's ability to complete the study of interfere with the evaluation of the study objectives (e.g. poorly controlled diabetes mellitus) * histologically confirmed SCC of same or other origin within the last five years * patient wants to withdraw for any reason during the study