SynOV1.1 Intratumoral Injection Study

Inclusion Criteria: 1. Voluntarily participates in the clinical trial study; fully understands the study and signs the ICF; and is willing to follow and will be able to complete all trial procedures. 2. Is ≥18 years old when signing ICF; male or female. 3. Has locally advanced or metastatic AFP-positive solid tumorsthat has relapsed or is refractory to standard cancer therapies, or where no standard therapies are available. AFP positive means that serum samples have levels of AFP\> 20 ng/ml during screening or an AFP immunohistochemistry \[IHC\] test of previous tumor tissue samples was positive. 4. Has at least one lesion that cannot be surgically removed which can be injected directly or through ultrasound (US) and/or computer tomography (CT) guidance. 5. Has at least one measurable tumor lesion. 6. Has a Child-Pugh score of Class A. 7. Has an ECOG performance status is 0 to 1 one week prior to the treatment. 8. Has an expected survival time of ≥ 12 weeks. 9. Has limited alterations in hematology or clinical chemistry: ANC≥ 1.5 × 10\^9/L, PLT≥ 75 × 109/L, TBIL≤ 1.5 ×ULN, AST and ALT≤5 × ULN, Alb≥ 2.8 g/dL, Crea≤ 1.5 × ULN, INR≤ 1.5 × ULN. 10. Agrees to provide archived or fresh tumor tissue specimens according to the individual's situation and blood samples. 11. A female participant who is postmenopausal, or whose serum pregnancy test result is negative. A woman who has not experienced a menstrual period for 12 months due to non-medical reasons is considered postmenopausal. 12. Female participants of child-bearing potential and male participants shall agree to take medically acceptable contraception measures (hormones, barrier, or abstinence) while on treatment and for 90 days following completion of treatment. Exclusion Criteria: 1. Received any anti-tumor treatment within the 4 weeks prior to study drug administration. The anti-tumor treatment includes surgery, ethanol injection, radiofrequency ablation, trans-arterial chemoembolization, intrahepatic chemotherapy, chemotherapy, biotherapy, immunotherapy, hormone, or radiotherapy. 2. Received a systemic treatment of glucocorticoid (Prednisone \> 10 mg/day or equivalent dose of a similar medicine) or other immunosuppressant treatment 14 days prior to study drug administration。 3. Administration of immune-regulating medicines within 14 days prior to study drug administration of the investigational drug。 4. Administration of live-attenuated vaccines within 4 weeks prior to study drug administration。 5. Previously treated with oncolytic viruses or other gene therapies. 6. Received treatment of unapproved investigational drugs within 4 weeks prior to study drug administration. 7. Currently participating in another clinical study, except for an observational or genetic (non-interventional) clinical study or a follow-up period. 8. Had major organ surgery (excluding biopsy) or had significant trauma within 4 weeks prior to study drug administration. 9. An adverse event from the previous anti-tumor therapy that has not resolved to ≤ Grade 1 or stabilized according to NCI-CTCAE v5.0, except for the adverse event of non-risk toxicity as judged by the investigator and sponsor. 10. Participants with clinical symptoms of central nervous system metastasis or meningeal metastasis, or other evidence demonstrating the central nervous system metastasis or meningeal metastasis has not been controlled. 11. History of meningococcal disease. 12. Evidence of uncontrolled severe comorbidity that may affect the participant's compliance with the study protocol, including severe liver disease (e.g. severe esophageal and gastric varices that require interventional treatment, cirrhosis, hepatic encephalopathy, or venous syndrome). 13. History of serious cardiovascular disease。 14. Participants who have third interstitial fluid beyond clinical control judged by the investigator. 15. History of tuberculosis infection or immunodeficiency, including participants who have tested positive for the human immunodeficiency virus (HIV) antibody. 16. Participants who are allergic to any component of the SynOV1.1 drug product. 17. Participants who are suffering from a known mental illness or substance abuse that may affect the objectivity of the trial. 18. Female participants who are pregnant, lactating, or who plan to get pregnant or to breastfeed during the trial. 19. Other reasons as judged by the investigator, including but not limited to highly vascularized tumors, exogenous, adjacent to necrotic areas, liver cysts, tumor site at the location with high risk of adverse events or not suitable for intratumoral injection, or tumor that will enhance the contraindications of CT/ MRI examination. 20. A significant bleeding event, as assessed by the investigator, that occurring within 12 months prior to study drug administration may increase the risk of intratumoral injection procedures. 21. Participants who cannot discontinue anticoagulant or antiplatelet medications prior to the intratumoral injection of SynOV1.1. 22. Participants who require treatment for active systemic infection. 23. Participants who have been diagnosed with bile duct cancer, bile duct liver cancer, fibrolamellar carcinoma, or hepatoblastoma based on histological finding. 24. Participants who have a severe inflammatory skin disease that currently requires medication or who have a history of severe eczema that requires medication. 25. Participants who received or plan to receive an organ transplant, such as a liver transplantation. 26. Participants who carry another type of tumor that has required active treatment in the past 5 years.