Vaporized Nicotine and Autonomic Control

Early Phase 1CompletedNCT04613609

Michigan Technological University16 enrolled

Overview

E-cigarettes are marketed as an alternative to smoking for those who want to decrease the health risks of tobacco. Tobacco cigarettes increase heart rate (HR) and arterial pressure, while reducing muscle sympathetic nerve activity (MSNA) through sympathetic baroreflex inhibition. The acute effects of e-cigarettes on arterial pressure and MSNA have not been reported: our purpose was to clarify this issue. Using a randomized crossover design, participants inhaled on a JUUL containing nicotine (59 mg/ml) and a similar placebo e-cigarette (0 mg/ml).

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

SINGLE

Enrollment

Conditions

Electronic Cigarette Use

Interventions

Electronic Cigarette containing nicotineDEVICE

Non-smokers used an electronic cigarette containing nicotine

Electronic Cigarette without nicotineDEVICE

Non-smokers used an electronic cigarette without nicotine

Eligibility

Sex: ALLMin age: 21 YearsMax age: 40 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: Exclusion Criteria: * Individuals with a history of hyperthyroidism * Women currently taking oral contraceptives, are pregnant or breast-feeding, or trying to become pregnant * Individuals currently taking prescription drugs. * Individuals with respiratory illnesses (e.g., asthma, chronic obstructive pulmonary disease, reactive airway disease, etc.) * Individuals with hypertension (systolic \>130 and/or diastolic \> 80). * Individuals with a history of tobacco or vaporized nicotine use. * Individuals who have been diagnosed with diabetes * Individuals who are under the age of 18 or over the age of 40

Locations (1)

Michigan Technological University

Houghton, Michigan, United States

Outcomes

Primary Outcomes

Blood pressure (measured from the finger)

Effects of electronic cigarettes on both systolic and diastolic arterial pressure.

Time frame: Experiments were separated by one month. Beat-to-beat arterial pressure was recorded for ten minutes at rest, during ten minutes of e-cigarette use, and for ten minutes during recovery. The last 5 minutes of each section were averaged.

Muscle sympathetic nerve activity (measured with the microneurography technique)

Effects of electronic cigarettes on muscle sympathetic nerve activity (MSNA)

Time frame: Experiments were separated by one month. MSNA was recorded for ten minutes at rest, during ten minutes of e-cigarette use, and for ten minutes during recovery. The last 5 minutes of each section were averaged.

Data from ClinicalTrials.gov

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