Lung Cancer Risk and Early Detection in Firefighters

Massachusetts General Hospital734 enrolled

Overview

This study will evaluate whether LDCT findings differ between firefighters and non-fighters, the relationship between occupational exposures and LDCT findings, and whether a proteomics assay can further risk-stratify screen-detected nodules among a study population of 850 current and retired firefighters and 1,120 matched controls.

Study Type

INTERVENTIONAL

Allocation

Purpose

SCREENING

Masking

NONE

Enrollment

734

Conditions

Lung Cancer Lung Diseases

Interventions

Low Dose CTDIAGNOSTIC_TEST

All participants will have a low dose chest CT either within one year of enrollment or after enrollment

Eligibility

Sex: ALLMin age: 40 YearsMax age: 80 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * 40-80 years of age or with 10 years of firefighting experience * Current or retired firefighters * No personal history of lung cancer * Willing and able to receive LDCT screening at MGH or who have been screened via LDCT within the past year at MGH or another institution, and are willing to release their images to the study Exclusion Criteria: * Any active cancer (undergoing treatment or diagnosed within the past 5 years)

Locations (1)

Massachusetts General Hospital

Boston, Massachusetts, United States

Outcomes

Primary Outcomes

Nodule detection rate

Frequency of nodule detection

Time frame: 12 months

High-risk nodule detection rate

Frequency of high-risk nodule detection. High risk is defined as a Lung RADS of 3 or 4. Lung RADS categories are as follows: 0) Incomplete; 1) Negative; 2) Benign appearance or behavior; 3) Probably benign; 4) Suspicious

Time frame: 12 months

Secondary Outcomes

Interstitial lung disease detection rate

Frequency of interstitial lung disease detection

Time frame: 12 months

Coronary artery calcification (CAC) ordinal scores

Frequency of high coronary artery calcification (CAC) ordinal scores. Possible scores range from 0 to 12 and high scores are defined as those greater than or equal to 10

Time frame: 12 months

Data from ClinicalTrials.gov

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