This prospective case-control study will compare the gut microbiota between the infants with febrile urinary tract infection and healthy infants.
The investigators hypothesize that the gut environment reflected by intestinal microbiota influences the risk of urinary tract infection. This prospective case-control study will compare the gut microbiota between the infants with febrile urinary tract infection and healthy infants. The investigators will sequence the V3-V4 of the bacterial 16SrRNA genes from the feces and analyze the sequencing data by QIIME2.
Study Type
OBSERVATIONAL
When the infants will be diagnosed with urinary tract infection, feces will be collected. Feces will be collected from healthy infants with informed consent.
Hallym University Kangnam Sacred Heart Hospital
Seoul, South Korea
The differential compositional analysis of the gut microbiota between healthy controls and infants with febrile urinary tract infection.
The investigators will sequence the V3-V4 of the bacterial 16SrRNA genes from the feces and analyze the sequencing data by QIIME2. From the OTU table, the investigators will conduct the differential compositional analysis of the gut microbiota between healthy controls and infants with febrile urinary tract infection, using the linear discriminant analysis and analysis of differential abundance taking sample variation into account in R program and QIIME2.
Time frame: An average of 1 year, after the completion of recruitment.
The differential functional analysis of the gut microbiota between healthy controls and infants with febrile urinary tract infection.
The investigators will predict the functional analysis from the OTU table and compare those results between healthy controls and infants with febrile urinary tract infection, using PICRUST2 analysis.
Time frame: An average of 1 year, after the completion of recruitment.
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