The data on long term natural history of benign nonfunctioning adrenal tumors (NFATs) are lacking. The aim is to identify clinical characteristics associated with tumor growth and progression to mild autonomous cortisol excess over time.
After being informed about the study, all patients with NFAT given written informed consent will underwent a control visit approximatly 10 years after initial visit at the outpateint clinic at the Department of Endocrinology, Diabetes and Metabolic Disease, University Medical Center Ljubljana, Ljubljana, Slovenia. The included patients will be divided in three groups regarding the BMI as follows: BMI \< 25 kg/m2, 25-30 kg/m2 and \> 30 kg/m2. The investigators will assess clinical, and laboratory parameters and CT findings at the follow up visit and compere them to baseline characteristics.
Study Type
OBSERVATIONAL
Enrollment
65
CT of abdomen
Department of Internal Medicine, Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia
Ljubljana, Slovenia
RECRUITINGNatural History of NFAT - horomnal activity
To determine if and in how many pateints NFAI progressed to MACE. NFAI: when cortisol after 1 mg overnight dexamethasone (ODST) suppression test is \< 50 nmol/l and no typical clinical signs of Cushing's syndrome are present. Pheochromocytoma and primary aldosteronism will be excluded. MACE: when cortisol after 1 mg overnight dexamethasone (ODST) suppression test is \> 50 nmol/l.
Time frame: 10 years
Natural History of NFAT - growth
To determine the change in size of NFAI on the CT scan (mm).
Time frame: 10 years
Natural History of NFAT - BMI
To determine the change in BMI and its correlation with outcome 1 and 2. Weight and height will be combined to report BMI in kg/m\^2.
Time frame: 10 years
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