Endocan Blood Level in Pulmonary Circulation

Centre Hospitalier Universitaire de Besancon30 enrolled

Overview

Endocan is a proteoglycan produced by the vascular endothelium. Animal studies suggested that the synthesis mainly happen in the pulmonary circulation, but this hypothesis has never been confirmed in humans.

The investigators will measure endocan levels in both pulmonary and systemic venous blood in patients undergoing on pump cardiac surgery. The main objective is to quantify the difference of endocan blood level between the pulmonary and the systemic circulation.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Cardiac Surgery Cardiopulmonary Bypass Lung

Eligibility

Sex: ALLMin age: 18 YearsMax age: 80 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Planned on pump coronary artery bypass surgery * Non opposition Exclusion Criteria: * Age \< 18 years old * Emergent surgery * Valvular replacement surgery * Combined cardiac surgery * Patients with inflammatory, infectious or evolutive neoplastic pulmonary disease * Patients with valvular problems, in particular aortic insufficiency * Patients who refuse to participate * Legal inability or disability * Patients who will probably not cooperate for the study * Pregnancy and/or breast feeding * Patients not in the Social security system * Patients in the exclusion period of another study

Outcomes

Primary Outcomes

Quantify the difference of Endocan blood levels between pulmonary and systemic circulation at the end of cardiopulmonary bypass

Blood samples will be collected at the same time in both pulmonary and systemic circulation at the end of cardiopulmonary bypass to measure Endocan blood level. The primary outcome will be the absolute difference between the Endocan blod level in the pulmonary circulation and in the systemic circulation.

Time frame: At the end of cardiopulmonary bypass

Secondary Outcomes

Kinetic of Endocan blood level in the systemic circulation during on pump cardiac surgery

Blood samples will be collected in the systemic circulation prior to the start of cardiopulmonary bypass, at the beginning of the cardiopulmonary bypass and at the end of cardiopulmonary bypass, and at the end of the surgery

Time frame: Prior to the start of cardiopulmonary bypass, at the beginning and at the end of cardiopulmonary bypass, and at the end of surgery

Central Contacts

Guillaume Besch, MD

CONTACT

3 81 21 89 58 gbesch@chu-besancon.fr

Data from ClinicalTrials.gov

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