Frequent premature ventricular beats (PVBs) are common, negatively affects the quality of life for many patients, and can lead to impaired contractile function. Rule-out of structural heart disease is key in the assessment of PVBs. Cardiac MR has a high sensitivity for structural heart disease, but the diagnostic gain from this resource-demanding procedure in the work-up of patients with PVBs is unknown. There is a need to establish the role of MR in the evaluation of patients with PVBs to improve diagnostic efficacy, establish treatment strategies, and promote further research. This project will answer three key questions: 1) What is the diagnostic gain from cardiac MR in patients with PVBs? 2) Is MR the real gold standard to rule-out structural heart disease in patients with PVBs? 3) Can non-invasive heart rate parameters guide the strategy for induction of PVBs during invasive electrophysiological procedures?
Study Type
OBSERVATIONAL
Enrollment
224
Invasive cardiac electrophysiological study with cathecholamine provocation and pacing procedures, as well as standard 3D mapping and PVC ablation
Standard ergometer bicycle test
Cardiac MRI with cine-imaging and late-gadolinium enhancement
24h 5 lead or 12 lead ECG recording
2D echocardiography
Conventional invasive coronary angiography or CT angiography as indicated
Oslo University Hospital
Oslo, Norway
RECRUITINGMRI-based evidence of structural heart disease
Evidence of structural heart disease from MRI compared to echocardiography
Time frame: 3-5 years
PVC induction vs PVC/HR-relationship
Correlation of method for induction of PVCs during invasive procedure vs PVC/HR relationship during CPET
Time frame: 3-5 years
EPS-based evidence of structural heart disease
Evidence of structural heart disease from invasive electrophysiology vs MRI and echo
Time frame: 3-5 years
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