Lung Diffusing Capacity for Nitric Oxide During Cycling Exercise

Thomas Radtke17 enrolled

Overview

This study investigates the test-retest reliability of the lung diffusing capacity for nitric oxide in healthy individuals during exercise.

The aim of this study of to evaluate the test-retest reliability of single-breath lung diffusing capacity measurements for nitric oxide (DLNO) in healthy individuals during light and moderate intensity cycling exercise. Healthy subjects will perform repeated single-breath DLNO measurements during light (i.e., at 50% of the first ventilatory threshold) and moderate intensity exercise (i.e., 80% of the first ventilatory threshold) on a stationary cycle ergometer.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Healthy

Eligibility

Sex: ALLMin age: 18 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Healthy * Age 18 yrs and older * Ability to follow study procedures and instructions in German Exclusion Criteria: * Any known cardiopulmonary or metabolic diseases (e.g., heart disease, diabetes mellitus etc) * Obesity (BMI \> 30kg/m2) * Smoking (ex-smoker allowed; if they stopped smoking at least one year before the examination) * Mental impairment leading to inability to cooperate * Respiratory infection in the last two weeks * Forced expiratory volume in 1s/ forced vital capacity (FEV1/FVC ratio) FEV1/FVC ratio \< lower limit of normal according to equations by Quanjer et al. Eur Respir J 2012.

Locations (1)

University of Zurich and University Hospital of Zurich

Zurich, Switzerland

Outcomes

Primary Outcomes

Diffusing capacity for nitric oxide (DLNO)

DLNO (in ml/min/mmHg) measured at 80% of the gas exchange threshold during cycling exercise.

Time frame: At second study visit

Diffusing capacity for nitric oxide (DLNO)

DLNO (in ml/min/mmHg) measured at 80% of the gas exchange threshold during cycling exercise.

Time frame: At third study visit, approximately 1-2 weeks after second study visit

Secondary Outcomes

Diffusing capacity for nitric oxide (DLNO)

DLNO (in ml/min/mmHg) measured at 50% of the gas exchange threshold during cycling exercise.

Time frame: At second study visit

Diffusing capacity for nitric oxide (DLNO)

DLNO (in ml/min/mmHg) measured at 50% of the gas exchange threshold during cycling exercise.

Time frame: At third study visit, approximately 1-2 weeks after second study visit

Diffusing capacity for carbon monoxide (DLCO)

DLCO (in ml/min/mmHg) measured at 50% of the gas exchange threshold during cycling exercise.

Time frame: At second study visit

Diffusing capacity for carbon monoxide (DLCO)

DLCO (in ml/min/mmHg) measured at 50% of the gas exchange threshold during cycling exercise.

Time frame: At third study visit, approximately 1-2 weeks after second study visit

Diffusing capacity for carbon monoxide (DLCO)

Agreement in DLCO (in ml/min/mmHg) measured at 80% of the gas exchange threshold during cycling exercise.

Data from ClinicalTrials.gov

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