Biomodulating Rotator Cuff Healing - A Proof of Concept Trial

Inclusion criteria * Patient is over 18 years old * Patient presents with a symptomatic full-thickness tear as diagnosed preoperatively on ultrasound, arthro-CT or MRI. * Absence of significant muscle atrophy or fatty infiltration of the affected tendon exceeding stage 2 of the Goutallier classification Exclusion criteria * Partial rotator cuff tear or other shoulder injury * Planned concomitant procedures other than subacromial decompression, acromioclavicular joint resection or biceps tenodesis/tenotomy * Irreparable rotator cuff tear * Patients who present with cartilage lesions greater than stage II of the Outerbridge classification (≥15mm diameter) on preoperative x-ray * Patient presenting with a known comorbidity that could affect the outcome of surgery (cervical radiculopathy, polyarthritis, neurological disease of the upper limb) * Patient not able to give informed consent