Idiopathic Pulmonary Fibrosis(IPF) is the most common idiopathic interstitial lung disease whose cause is unknown. With age and gender, socio-economic factors are the most influential indicators of health. At present there is very little data on socio-economic factors in the IPF. The investigators hypothesize that a lower socio-economic level and / or exposure to various air pollutants may influence the IPF's natural history, including the severity of diagnosis and prognosis of the IPF. The investigators also hypothesize that the deleterious effect of air pollutants is modulated by individual susceptibility (shorter telomeres) and that this effect is related to oxidative stress and shortening of telomeres.
Idiopathic Pulmonary Fibrosis is the most common idiopathic interstitial lung disease whose cause is unknown. However, it remains a rare disease, there is an incidence of approximately 4400 new patients per year in France. It is a serious disease with few therapeutic options and a median survival after diagnosis around 36 months. It is also responsible for high morbidity, with a marked deterioration in quality of life (dyspnea, cough, fatigue and anxiodepressive disorders) and significant functional impairment (respiratory failure) With age and gender, socio-economic factors are the most influential indicators of health. At present there is very little data on socio-economic factors in the IPF. The investigators hypothesize that a lower socio-economic level and / or exposure to various air pollutants may influence the IPF's natural history, including the severity of diagnosis and prognosis of the IPF. The investigators also hypothesize that the deleterious effect of air pollutants is modulated by individual susceptibility (shorter telomeres) and that this effect is related to oxidative stress and shortening of telomeres.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
OTHER
Masking
NONE
Enrollment
200
Blood sample performed at the inclusion and during the follow-up.
001 - Service Pneumologie
Bobigny, Avicenne, France
RECRUITING002 - Service Explorations Fonctionnelles Respiratoires
Bobigny, Avicenne, France
RECRUITING003 - Service Pneumologie
Paris, Bichat, France
ACTIVE_NOT_RECRUITING016 - Service Pneumologie
Caen, CHU Caen Normandie, France
ACTIVE_NOT_RECRUITING010 - Service Pneumologie
Dijon, CHU Dijon, France
ACTIVE_NOT_RECRUITING013 - Service Pneumologie
Grenoble, CHU Grenoble, France
ACTIVE_NOT_RECRUITING008 - Service Pneumologie
Lille, CHU Lille, France
ACTIVE_NOT_RECRUITING015 - Service Pneumologie
Montpellier, CHU Montpellier, France
NOT_YET_RECRUITING007 - Service Pneumologie
Rennes, CHU Pontchaillou, France
RECRUITING011 - Service Pneumologie
Strasbourg, CHU Strasbourg, France
ACTIVE_NOT_RECRUITING...and 6 more locations
Determine if the household income is associated with the severity of the IPF at inclusion
Patients will be classified into three groups: "lower" standard of living, "average" level and "higher" level. These groups are respectively defined by wages : less than 1000 euros, greater than or equal to 1000 euros and less than 4000 euros, and greater than or equal to 4000 euros. The severity of the IPF at baseline will be defined by the respiratory functional impact: a forced vital capacity (FVC) of less than 50% and / or a Carbon monoxide diffusion capacity of less than 30%.
Time frame: Enrollment
Describe the general and specific external environment of patients with IPF
Collection of data on the general and specific external environment on patients with IPF
Time frame: Enrollment
Determine the impact of socio-economic factors and environmental factors (occupational domestic exposures and air pollution) on the severity of the IPF
Collection of data about socio-economic and environmental factors, and about severity on patients with IPF
Time frame: Enrollment
Determine the impact of socio-economic factors and environmental factors (occupational domestic exposures and air pollution) on the quality of life
Collection of data about socio-economic and environmental factors, and about quality of life on patients with IPF
Time frame: Enrollment
Determine the impact of socio-economic factors and environmental factors (occupational domestic exposures and air pollution) on the occurrence of an Acute Exacerbation
Collection of data about socio-economic and environmental factors, and about occurrence of an Acute Exacerbation on patients with IPF
Time frame: 24 months
Determine the impact of socio-economic factors and environmental factors (occupational domestic exposures and air pollution) on the progress of the IPF
Collection of data about socio-economic and environmental factors, and about progression of IPF on patients with IPF
Time frame: 24 months
Determine the impact of socio-economic factors and environmental factors (occupational domestic exposures and air pollution) on the mortality
Collection of data about socio-economic and environmental factors, and about mortality of patients with IPF
Time frame: 24 months
Determine the impact of socio-economic factors and environmental factors (occupational domestic exposures and air pollution)on the existence and type of comorbidities
Collection of data about socio-economic and environmental factors, and about existence and type of comorbidities on patients with IPF
Time frame: Enrollment
Determine the impact of socio-economic factors and environmental factors (occupational domestic exposures and air pollution)on the diagnostic and management delay
Collection of data about socio-economic and environmental factors, and about diagnostic and management delay on patients with IPF
Time frame: Enrollment
Determine the impact of socio-economic factors and environmental factors on therapeutic decisions: anti-fibrotic treatments, access to transplantation
Collection of data about socio-economic and environmental factors (occupational domestic exposures and air pollution), and about therapeutic decisions (anti-fibrotic treatments, access to transplantation) on patients with IPF
Time frame: 24 months
Determine if the deleterious effect of air pollutants on the decline of respiratory function is dependent on the size of the telomeres
Collection of data about deleterious effect of air pollutants on the decline of respiratory function and about the length of telomers calculated with T/S ratio. Blood samples will be performed for analysis of biomarkers and oxidative stress in IPF, measurement of telomere length, MUC5B, TOLLIP and GSTT1 polymorphisms.
Time frame: 24 months
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.