The Influence of Antibiotics on the Incidence of Biliary Tract Infections After PTCD for Malignant Obstructive Jaundice

Inclusion Criteria: 1. 18-80 years old; 2. ECOG score 0-1 before operation; 3. Patients diagnosed as pancreatic head cancer and periampullary cancer according to preoperative imaging, including ampullary cancer, extrahepatic bile duct cancer and duodenal papillary cancer; 4. Bilirubin\>200 mmol/L before PTCD , and the duration of PTCD continuous drainage \>2 weeks; 5. Volunteer to participate and sign the informed consent form; Exclusion Criteria: 1. Decompensated liver cirrhosis, acute and chronic hepatitis and other diseases before surgery; 2. A history of other malignant tumors before surgery; 3. Duration of preoperative PTCD drainage\<2 weeks; 4. Jaundice caused by other reasons besides cancer around the ampulla and cancer of the head of the pancreas;