Use of Reticulocyte Ratio and Neutrophil / Lymphocyte Ratio in the Diagnosis of Ventilator-associated Pneumonia

N/ACompletedNCT04620941

Muğla Sıtkı Koçman University35 enrolled

Overview

In this study, the utility of changes in the ratio of Ret-He and NLR as an early inflammation marker for VAP will be evaluated.

Ventilator-associated pneumonia (VAP) is one of the most common nosocomial infections in the intensive care unit, affecting one third of patients requiring mechanical ventilation for a noninfectious reason. In the case of inflammation, iron retention increases in the reticuloendothelial system cells; hemoglobin (Hb) synthesis is reduced. It has been reported that the ratio of reticulocyte / hemoglobin (Ret-He) decreases in the early period in community-acquired pneumonia patients and may be a guide as a marker of inflammation. In addition, the neutrophil / lymphocyte ratio (NLR) is a parameter studied in the hemogram panel. It provides a clue to both the presence of infection and the focus of the infection. In this study, the utility of changes in the ratio of Ret-He and NLR as an early inflammation marker for VAP will be evaluated.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Ventilator-associated Pneumonia (VAP)

Interventions

reticulocyte/hemoglobin (Ret-He) ratioDIAGNOSTIC_TEST

Ret-He values will be studied on the day (1st day), 4th and 7th days of the diagnosis of ventilator-associated pneumonia in patients hospitalized in the intensive care unit.

Eligibility

Sex: ALLMin age: 18 YearsMax age: 70 Years

Medical Language ↔ Plain English

Inclusion Criteria: -Patients who need mechanical ventilation for longer than 48 hours for a noninfectious reason in the intensive care unit Exclusion Criteria: * Pulmonary or extrapulmonary infection before mechanical ventilation, * severe immunosuppression, * bleeding in the gastrointestinal system, * using corticosteroids, * neoplastic disease history

Locations (1)

Mugla Sitki Kocman Universty

Muğla, Kötekli, Turkey (Türkiye)

Outcomes

Primary Outcomes

Early inflammation markers for VAP

To investigate the use of NLR and Ret-He value as early inflammation markers for VAP.

Time frame: 7 days

Secondary Outcomes

morbidity and mortality

To compare the effects of Ret-He and NLR values on morbidity and mortality with other inflammation markers

Time frame: 7 days

Data from ClinicalTrials.gov

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