In 2020, IntraCerebral Haemorraghe (ICH) remains the most devastating type of stroke. Besides stroke unit care, no specific treatment has been proven effective yet. Perihaematomal oedema (PHO) could be a promising therapeutic target. However, the mechanisms, the natural history as well as the clinical impact of this PHO remain unclear. The COPITCH study has been designed to answer these questions
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
DIAGNOSTIC
Masking
NONE
Enrollment
500
Brain MRI will include differents sequences.
Biological biomarkers will include a set of systemic inflammatory markers
CHU de Lille
Lille, France
RECRUITINGPoor functional outcome defined as a modified Rankin Scale of 4 or more
Time frame: at 3 months
overall distribution of the modified Rankin scale at 3- and 12 months
The modified Rankin Scale (mRS) is a commonly used scale for measuring the degree of disability or dependence in the daily activities of people who have suffered a stroke or other causes of neurological disability. The scale runs from 0-6, running from perfect health without symptoms to death.
Time frame: at 3 months and 12 months
Early neurological deterioration defined as more than 4 points on the NIHSS score
The NIHSS score (NIH Stroke Scale) is used to monitor the progression of an ischemic or hemorrhagic stroke. It is rated from 0 to 42 points. Depending on the result, a distinction is made from Minor stroke to Severe stroke
Time frame: at 96 hours
all-cause mortality at 3 and 12 months
Time frame: at 3 and 12 months
Cognitive decline
Cognitive decline defined as a score on MOCA test below 27
Time frame: at 3 months, at 12 months
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