The Evaluation of the Safety and Effectiveness of ANIMERS Chiara LA and JUVÉDERM VOLUMA® for Aging Mid-Face

Inclusion Criteria: 1. Age 30 to 60 years of male or female 2. MidFace Volume Deficit Scale (MFVDS) of midface graded 2 to 5 by evaluator. Exclusion Criteria: 1. Injection site with infection or other skin diseases present which may affect the evaluation 2. With medical history of chromatosis, discoloration, keloid formation, hypertrophic scarring at midface 3. With permanent implants or planning to receive permanent implants during the study period at the injection sites 4. Hyaluronate facial dermal implant injection or other impermanent dermal fillers injection at injection sites within the past 6 months 5. With under-eye facial Botox or fat injection within the past 6 months or planning to receive under-eye facial Botox or fat injection during the study period 6. With Major surgery 3 months before the start of the trial 7. With under-eye facial chemical or lasers peeling, non-invasive skin tightening, thermocool within the past 3 months or planning to receive these aesthetic procedures during the study period 8. With systemic immunosuppressive therapy or systemic corticosteroids within the past 2 months or planning to receive these therapies during the study period (subjects who have received inhaled/intranasal corticosteroids could be considered to include.) 9. With clinical meaningful coagulation disorders, underdoing anticoagulant treatment or within the past 10 days, or taking blood circulation promotion and blood stasis movement medications 10. With epilepsy or porphyria 11. With congenital or idiopathic methemoglobinemia or glucose-6-phosphate dehydrogenase deficiency 12. With analgesic dependence, analgesics within the past 2 weeks or planning to receive analgesics during the study period 13. With history of hypersensitivity or allergy to lidocaine, amide anesthetics, hyaluronic acid or any component of the device; Gram-positive bacterial or Streptococcus proteins; other severe hypersensitivity history unsuitable for participating in the study 14. Planning to undergo any surgery which may cause significant body weight change (such as bariatric surgery) or take any medication which may cause significant body weight change 15. Pregnant, planning pregnancy or in breastfeeding females 16. Participated in clinical study of other device or drug and have not terminated within the past 30 days -Other circumstances which judged to be unsuitable for participating in the study by the investigator