Diuresis, Functional Bladder Capacity and LUTS in CKD and ESRD Patients.

Universitair Ziekenhuis Brussel128 enrolled

Overview

The aim of the study is to evaluate the prevalence of LUTS in patients with moderate to severe (Stage IIIb), severe (Stage IV) CKD and ESRD : Stage V CKD) without renal transplantation (both pre-dialysis and dialysis patients). The study will also investigate the correlation between the diuresis, functional bladder capacity and LUTS in this population. By means of the obtained results, the investigators hope to be able to predict at which values of diuresis and functional bladder capacity these patients will start to develop LUTS. The investigators will also evaluate the impact of LUTS on the quality of life of these patients.

Pre-dialysis and peritoneal dialysis (home dialysis) and hemodialysis patients will be asked to fill in a 24h voiding diary the day prior to the control visit or dialysis session, or this can be registered the day of planned 24h urine collection. All patients will be asked to fill a ICIQ-LUTS questionnaire. The ICIQ-LUTS questionnaire is a validated questionnaire to investigate the presence of LUTS in a non-invasive way: ICIQ-FLUTS(female lower urinary tract symptoms) for female patients and ICIQ-MLUTS(male lower urinary tract symptoms) for male patients. Following patient data will be registered: * Age * Gender * eGFR(estimated Glomerular Filtration Rate) (CKD-EPD) * Cause of CKD-ESRD * In case of dialysis: duration modality (hemodialysis or peritoneal dialysis) * Antecedents * Comorbidities * Medication * 24h voiding diary * LUTS questionnaire

Study Type

INTERVENTIONAL

Allocation

Purpose

HEALTH_SERVICES_RESEARCH

Masking

NONE

Enrollment

128

Conditions

Lower Urinary Tract Symptoms

Interventions

ICIQ questionnaireDIAGNOSTIC_TEST

questionnaire

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * \>18years old * GFR(CKD-Epi) \< 45 ml/min and persisting minimal diuresis * able to read and understand Dutch, French or English Exclusion Criteria: * \<18 years old * eGFR (CKD-EPI) \> 45 ml/min * eGFR (CKD-EPI) \< 45 ml/min and \> 3 months absent persisting minimal diuresis * unable to read and understand Dutch, French or English * renal transplant recipients.

Locations (3)

Valida

Brussels, Brussels Capital, Belgium

universitair ziekenhuis VUB

Jette, Vlaams Brabant, Belgium

AZ Jan Portaels

Vilvoorde, Vlaams Brabant, Belgium

Outcomes

Primary Outcomes

prevalence of LUTS in ESRD by ICIQ questionnaire

A ICIQ male or female LUTS questionnaire will be taken by investigator in all patient who signed IC.

Time frame: up to 6 month

Secondary Outcomes

evaluation of bladder capacity in ESRD

Patient will be asked to keep an 24hour voiding diary This consist in keeping a record of the time of voiding and the volume of urine passed in ml each void. This will be measured in milliliter

Time frame: up to 6 month

Data from ClinicalTrials.gov

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