Uganda Housing Modification Study

Infectious Diseases Research Collaboration, Uganda2,422 enrolled

Overview

To explore housing modification as a malaria control intervention, and to assess the degree to which it may offer protection in moderate to high malaria endemicity settings, we propose a two-phase study evaluating epidemiological and entomological effectiveness, cost-effectiveness, feasibility, and acceptability of housing modification in Uganda. The first phase will be a pilot implementation assessing the feasibility of candidate housing modification interventions, followed by a cluster randomised control trial of the most effective, scalable, and cost-effective interventions.

The study will be conducted in two phases, beginning with a pilot (Phase I). The aim of the pilot will be to develop and test four types of housing modifications in both modern houses (those with brick or stone walls) and traditionally constructed houses (those with mud walls). The housing modifications will include: (1) full house screening (eaves and windows), (2) partial house screening (eaves or ceiling), (3) eave tubes, and (4) eave ribbons. Community input will be sought during the development of the housing prototypes. In the pilot, all 4 interventions will be implemented in both modern and traditional houses, plus a control arm in each group. All households will have access to PBO LLINs. Community input will be sought during the development of the housing prototypes. The pilot will include 10 arms in total, each consisting of 20 households, equal to 200 households (160 in the intervention and 40 in the control arm) in total. The feasibility and effectiveness of the interventions will be assessed through a qualitative study (FGDs and interviews), evaluation of the costs and implementation of the interventions, and entomology surveys (using CDC light traps). One to two housing interventions will be selected for Phase II following the review and discussion of the pilot results with the trial steering committee. Phase II will include a cluster-randomised trial. A cluster will be defined as a village (or segment of a village consisting of \~100 households). In the cluster-randomised trial, up to 2 interventions vs 1 control arm will be assessed in 20 clusters per arm (60 clusters total). The clusters will be non-contiguous, with a buffer zone of 300-500m. All households in the selected clusters will have PBO LLINs; households in intervention clusters will also receive the specified housing modifications. The impact of the interventions will be assessed through a cohort study, cross-sectional community surveys, entomology surveillance, a qualitative study, and an economic evaluation. The primary outcome of the trial will be clinical malaria incidence in children aged \< 60 months as measured in the cohort study.

Study Type

Conditions

Malaria Anemia

Interventions

Eave TubesOTHER

The eave tubes are PVC tubes with a diameter of 15 cm installed in the outer wall of occupied rooms (e.g. bedrooms and living rooms but not storage rooms) at 1.5-2 m intervals, fitted with electrostatic mesh inserts coated with insecticides. No additional screening will be done. All households will be provided with piperonyl butoxide (PBO) long-lasting insecticidal nets (LLINs) - one for every two residents.

Eave RibbonsOTHER

Eave ribbons are 15 cm-wide triple-layered hessian fabrics (burlap-line fabric woven from sisal fibres, procured locally), in lengths starting 1 m that can be attached to houses using nails, adhesives or Velcro, without completely closing eave-spaces. The eave ribbons will be treated by study staff with a commonly used spatial repellent, transfluthrin. Eave ribbons will be retreated by study staff after 6 months (only in Phase II, if selected for inclusion in the cluster-randomised trial). All households will be provided with piperonyl butoxide (PBO) long-lasting insecticidal nets (LLINs) - one for every two residents.

Eligibility

Sex: ALLMax age: 14 YearsHealthy volunteers:

Medical Language ↔ Plain English

Phase I Inclusion criteria * At least one adult aged 18 years or older present * Agreement of the adult resident to provide informed consent for the pilot study Phase II Cohort Study Inclusion Criteria: * Household considered their primary residence * Child aged less than 59 months * Agreement to come to the study clinic for any febrile illness * Agreement to avoid antimalarial medications outside the study * Provision of written informed consent (for parent or guardian in case of children) Cross-sectional Community Survey - Household Survey Inclusion Criteria: * At least one household resident between 6 months and 14 years of age present (with an adult caregiver willing to provide informed consent for the clinical survey) * At least one adult aged 18 years or older present * Adult is a usual resident who slept in the sampled household on the night before the survey * Agreement of the adult resident to provide informed consent for the household survey Exclusion Criteria: * Dwelling destroyed or not found * Household vacant * No adult resident home on more than 3 occasions Cross-sectional Community Survey - Clinical Survey Inclusion Criteria: * Child aged 6 months to 14 years * Usual resident who was present in the sampled household on the night before the survey * Agreement of parent/guardian to provide informed consent * Agreement of child aged 8 years or older to provide assent Exclusion Criterion: * Child not home on day of survey Recruitment of Field Workers for entomology activities (human landing catches). Inclusion Criteria: * Willingness to take chemoprophylaxis for malaria * Willingness to abstain from alcohol during working hours * No significant past medical history.

Locations (1)

Infectious Diseases Research Collaboration

Kampala, Central Region, Uganda

Outcomes

Primary Outcomes

Incidence of malaria

Number of incident episodes of clinical malaria per time of observation. Incident episodes of malaria defined as any treatment for malaria \> 14 days after any prior treatment for malaria