This study is carried on in Wuchang Hospital in Wuhan, China. The investigators plan to recruit 80 patients with COVID-19 and 80 matched healthy control. Using the design of case-control study, the study aims to assess the neurocognitive functions such as executive function and attentional bias in recovered patients with COVID-19 under normal and stress conditions, and to analyze the influencing factors of neurocognitive functions, such as mental health conditions, inflammation indicators and cardiopulmonary function.
Study Type
OBSERVATIONAL
Enrollment
160
8-min oral calculation and 5-min speech
Wuhan Wuchang Hospital
Wuhan, Hubei, China
RECRUITINGworking memory
assessed by the n-back task, including 0-back, 1-back and 2-back
Time frame: 10 minutes
Cognitive flexibility
assessed by the trail-making task
Time frame: 3 minutes
Inhibitory control
assessed by the stroop task
Time frame: 10 minutes
Attention Bias
assessed by the dot-probe task
Time frame: 15 minutes
Serum TNFalpha
Concentration of serum TNFalpha in ng/ml will be assessed by ELISA
Time frame: 1 day
Serum IL-6
Concentration of serum IL-6 in ng/ml will be assessed by ELISA.
Time frame: 1 day
CRP
hypersensitive C-reactive protein(hs-CRP) in mg/L will be assessed by Turbidimetric inhibition immuno assay.
Time frame: 1 day
Depression
assessed by Self-Rating Depression Scale, which is consist of 20 items scoring 1 to 4.
Time frame: 3-5 minutes
Anxiety
assessed by Self-Rating Anxiety Scale, which is consist of 20 items scoring 1 to 4.
Time frame: 3-5 minutes
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.
PTSD
assessed by PTSD Checklist for DSM-5 (PCL-5)
Time frame: 3-5 minutes
Sleep
assessed by Pittsburgh sleep quality index (PSQI)
Time frame: 3-5 minutes
General cognition
assessed by Montreal - Cognitive Assessment (MoCA)
Time frame: 8-10 minutes
Cardiopulmonary function 1
maximal inspiration pressure(MIP), maximal expiration pressure(MEP)
Time frame: 15 minutes
Cardiopulmonary function 2
Assessed by the 6-minutes' walk test
Time frame: 10 minutes