Erectile dysfunction (ED) is the persistent inability to attain and maintain a sufficient erection to permit satisfactory sexual performance. ED, a condition closely related to cardiovascular morbidity and mortality, is frequently associated with obesity. The importance of reducing cardiovascular risk factors remains fundamental to the overall vascular good health of the man, and that includes sexual vascular health. ED shares similar modifiable risks factors with coronary artery disease (CAD). Lifestyle modification that targets CAD risk factors may also lead to improvement in ED.
Sixty obese men with ED complaints will be divided to two groups, exercised and non-exercised groups; n= 30 patients in every group. Both groups will receive five milligrams of tadalafil one time per day for 8 weeks but the exercised group only will receive - in addition to tadalafil - combined continuous and interval aerobic training, 3 session weekly for 8 weeks after detecting their target heart rate via the cardiopulmonary exercise test.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Enrollment
60
(n=30) will be sedentary obese men with ED. All participants will receive five milligrams of tadalafil, one time per day, in addition to 3 sessions, per week, of combined continuous and interval aerobic exercise for eight weeks
(n=30) will be sedentary obese men with ED. All participants will receive five milligrams of tadalafil, one time per day, for eight weeks
Cairo Unoversity
Giza, Egypt
RECRUITINGFive-Item Version of International Index of Erectile Function (IIEF-5)
It is a questionnaire of five questions to diagnose ED in male patients
Time frame: It will be measured after eight weeks of training
Triglycerides
It will be measured via a venous blood sample
Time frame: It will be measured after eight weeks of training
High density lipoprotein
It will be measured via a venous blood sample
Time frame: It will be measured after eight weeks of training
Insulin
It will be measured via a venous blood sample
Time frame: It will be measured after eight weeks of training
Fasting blood glucose
it will be measured via a blood glucose meter
Time frame: It will be measured after eight weeks of training
The HOMA-IR (Homeostatic Model Assessment for Insulin Resistance
HOMA-IR = \[fasting insulin (μU/mL) × fasting glucose (mmol)\]/22.5
Time frame: It will be measured after eight weeks of training
body mass index
It will be obtained by dividing the weight in Kilograms on the squared height in meter
Time frame: It will be measured after eight weeks of training
systolic blood pressure
it will be measured by a manual sphygmomanometer
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Time frame: It will be measured after eight weeks of training
diastolic blood pressure
it will be measured by a manual sphygmomanometer
Time frame: It will be measured after eight weeks of training
Waist circumference
it will be measured by inelastic tape at the umbilicus level
Time frame: It will be measured after eight weeks of training