Previous study showed that the proportions of hemorrhagic Infarction after intravenous thrombolysis were 24.2% and 32.5% in the control group and the alteplase group, and most of them were asymptomatic. Hemorrhagic Infarction was a part of the natural progression after acute ischemic stroke. Previous study have shown no significant relationship between hemorrhagic Infarction and poor outcome in acute ischemic stroke (AIS) patients. In this study, a randomized controlled trial will be conducted to explore the efficacy and safety of early antiplatelet therapy after hemorrhagic infarction in acute ischemic stroke treated with intravenous thrombolysis.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Enrollment
294
Early Antiplatelet Therapy is administered within 24 to 48 hours after stroke onset and the dose is determined by the clinician. Aspirin was chosen for antiplatelet therapy.
Antiplatelet therapy will be delayed to beyond 48 hours after stroke onset and may not be initiated until hemorrhagic Infarction has been confirmed absorbed.
the second affiliated hospital of Zhejiang University
Hangzhou, China
RECRUITINGThe proportion of patients with modified Rankin scale (mRS) ≤2
The proportion of patients with modified Rankin scale (mRS) ≤2 at 90 days, on which scores range from 0 (no neurologic deficit) to 6 (death)\].
Time frame: 90 days
Hemorrhage enlargement after intravenous thrombolysis
Hemorrhage enlargement after intravenous thrombolysis at 7 days
Time frame: 7 days
Hemorrhage reduction after intravenous thrombolysis
Hemorrhage reduction after intravenous thrombolysis at 7 days
Time frame: 7 days
the progress of National Institute of Health Stroke Scale (NIHSS) scores
the progress of National Institute of Health Stroke Scale (NIHSS) scores at 7 days, on which scores range from 0 (no neurologic deficit) to 42 (severe)\]
Time frame: 7 days
the distribution of modified Rankin scale (mRS)
the distribution of modified Rankin scale (mRS) at 90 days, on which scores range from 0 (no neurologic deficit) to 6 (death)\]
Time frame: 90 days
Recurrence rate of acute ischemic stroke
Recurrence rate of acute ischemic stroke at 90 days
Time frame: 90 days
Recurrence rate of cerebrovascular disease
Recurrence rate of cerebrovascular disease at 90 days
Time frame: 90 days
Recurrence rate of acute ischemic stroke
Recurrence rate of acute ischemic stroke at 1 years
Time frame: 1 year
Recurrence rate of cerebrovascular disease
Recurrence rate of cerebrovascular disease at 1 year
Time frame: 1 year
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