COVID-19 infection has been associated with numerous cardiac manifestations. Indeed, SARS-CoV-2 may impact on cardiovascular system through a direct myocardial infection or a secondary cardiac involvement due to hypoxia or metabolic supply-demand imbalance or prothrombotic inflammatory state. As a consequence of and besides acute myocardial damages, COVID-19 could also determine chronic cardiovascular consequences, with a significant impact on long-term prognosis, quality of life and functional capacity of COVID-19 survivors. On this basis, we aim to define the clinical and prognostic effects of myocardial involvement in COVID-19 patients.
COVID-19 infection has been associated with numerous cardiac manifestations. Indeed, SARS-CoV-2 may impact on cardiovascular system through a direct myocardial infection or a secondary cardiac involvement due to hypoxia or metabolic supply-demand imbalance or prothrombotic inflammatory state. As a consequence of and besides acute myocardial damages, COVID-19 could also determine chronic cardiovascular consequences, with a significant impact on long-term prognosis, quality of life and functional capacity of COVID-19 survivors. On this basis, we aim to define the clinical and prognostic effects of myocardial involvement in COVID-19 patients, with a 1-month and 6-month follow-up composed of clinical evaluation, electrocardiogram, trans-thoracic echocardiogram, cardiovascular magnetic resonance, chest computerized tomography scan and cardiopulmonary exercise test.
Study Type
OBSERVATIONAL
Enrollment
500
Humanitas Research Hospital
Rozzano, Milan, Italy
RECRUITINGCentro Cardiologico Monzino
Milan, Italy
RECRUITINGIRCCS Auxologico San Luca
Milan, Italy
RECRUITINGIRCCS San Donato
Milan, Italy
RECRUITINGIRCCS Istituti Clinici Scientifici Maugeri
Pavia, Italy
RECRUITINGCardiovascular mortality
Mortality due to cardiovascular causes at 1 month after hospitalization
Time frame: 1 month
Cardiovascular mortality
Mortality due to cardiovascular causes at 6 months after hospitalization
Time frame: 6 months
All-cause mortality
Mortality due to all causes at 1 month after hospitalization
Time frame: 1 month
All-cause mortality
Mortality due to all causes at 6 months after hospitalization
Time frame: 6 months
Major adverse cardiovascular events (myocardial infarction, cerebrovascular accident, hospitalizations due to heart failure, revascularizations, cardiovascular mortality)
Major adverse cardiovascular events at 1 month after hospitalization
Time frame: 1 month
Major adverse cardiovascular events (myocardial infarction, cerebrovascular accident, hospitalizations due to heart failure, revascularizations, cardiovascular mortality)
Major adverse cardiovascular events at 6 months after hospitalization
Time frame: 6 months
NYHA class
NYHA functional class: from I (no limitation of physical activity) to IV (severe limitation with symptoms at rest)
Time frame: 6 months
Left ventricular systolic function (cardiac magnetic resonance, echocardiography)
Left ventricular systolic function evaluated with multimodality imaging
Time frame: 6 months
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