Development of Urologic Registry for Personalized Medicine in Patients With Urologic Malignant Diseases by Analyzing Microbiome

Yonsei University3,000 enrolled

Overview

Genitourinary malignancies such as prostate cancer, renal cell cancer, and bladder cancer in Korean population have been increased due to the aged population and the westernized lifestyles. With the advancement of technologies, studies have found that microbiome not only affects human physiological functions, such as metabolism, immunity, and haematopoiesis, but also plays a significant role in the development and progression of malignancies. However, the investigation of microbiome in urological malignances have been limited and few studies have been reported. Therefore, the investigator tried to evaluate the usefulness of microbiome in detection and monitoring of urological malignancies in Korean population. This study aims to use microbiome in tissue, plasma, stool and urine for the diagnosis, disease progression monitoring and therapeutic response evaluation. This study plan includes building big databases for microbiome of urological malignancies in Korean population.

Study Type

OBSERVATIONAL

Enrollment

3,000

Conditions

Urological Malignancies Prostate Cancer Renal Cell Cancer Bladder Cancer Ureter Cancer

Medical Language ↔ Plain English

Inclusion Criteria: * Patients diagnosed as urological malignancies (prostate cancer, renal cell cancer, bladder cancer, and ureter cancer) * Patients who have undergone surgeries due to urological malignancies in Severance Hospital, Sinchon from 2020.10 and 2030.10 * Those who agree to give permission to use their human source information * Those who agree with this study Exclusion Criteria: * Those who do not agree with this study * Vulnerable participants who are likely to be vulnerable to coercion or undue influence or lack decision-making

Outcomes

Primary Outcomes

Correlation between tissue bacteria composition and prevalence of urological malignancies

evaluate and compare the bacteria composition in tissue samples in urological malignancies (prostate cancer, renal cell cancer, bladder cancer, and ureter cancer) with healthy control group

Time frame: within 2 weeks after the surgery

Correlation between plasma bacteria composition and prevalence of urological malignancies

evaluate and compare the bacteria composition in plasma samples in urological malignancies (prostate cancer, renal cell cancer, bladder cancer, and ureter cancer) with healthy control group

Time frame: within 2 weeks after the surgery

Correlation between stool bacteria composition and prevalence of urological malignancies

evaluate and compare the bacteria composition in stool samples in urological malignancies (prostate cancer, renal cell cancer, bladder cancer, and ureter cancer) with healthy control group

Time frame: within 2 weeks after the surgery

Correlation between urine bacteria composition and prevalence of urological malignancies

evaluate and compare the bacteria composition in urine samples in urological malignancies (prostate cancer, renal cell cancer, bladder cancer, and ureter cancer) with healthy control group

Time frame: within 2 weeks after the surgery

Secondary Outcomes

Correlation of bacteria composition and tumor response assessed using the Response Evaluation Criteria in Solid Tumors version 1.1 (RECIST v1.1)

Association between bacteria composition and oncological prognosis, progression, and therapeutic response in urological malignancies

Time frame: within 10 years after the surgery

Development of Urologic Registry for Personalized Medicine in Patients With Urologic Malignant Diseases by Analyzing Microbiome

Overview

Conditions

Eligibility

Locations (1)

Outcomes

Primary Outcomes

Secondary Outcomes

Central Contacts