The investigators will perform this study to prospectively compare the clinical outcome after percutaneous microwave ablation(MWA) and breast conserving surgery of benign and malignant breast lesion under ultrasound (US) guidance.
A total of more than 300 patients diagnosed with breast tumor in multiple centers will be recruited in this study and underwent US-guided percutaneous MWA and breast conserving surgery treatment. Information for each patient includes demographics; longest diameters of tumors; tumor numbers; tumor pathological type; location of tumor according to whether adjacent to skin, pectoralis, areola and papilla. Ablation variables including session, puncture, time, and power; complete ablation, complications; reduction in volume, palpability, pain and cosmetic satisfying outcomes,recurrence,survival will be compared and analyzed.
Study Type
INTERVENTIONAL
Allocation
NON_RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
300
Microwave ablation has the advantages of aesthetics, precise positioning, minimally invasive and painless for patients with early breast cancer.The tumor can be completely killed without injurying adjacent tissue. Some studies have suggested MWA is a safe and effective therapy for the treatment of breast cancer.
The treatment of early-stage breast cancer tends to be less-invasive including less morbidity, shorter hospitalization, and improved cosmetic results. Many reports have concluded that there was no difference between breast-conserving surgery and the traditional radical mastectomy for early stage breast cancer in time to distant metastases or overall survival, so breast-conserving surgery is becoming an alternative treatment for early-stage breast cancer.
Chinese PLA General Hospital
Beijing, Beijing Municipality, China
RECRUITINGoverall survival：Defined as the length of time from the beginning of treatment to death or the last follow-up (if no death)
Defined as the length of time from the beginning of treatment to death or the last follow-up (if no death)
Time frame: 5 years
cosmetic satisfaction：Patients are rated whether they are satisfied with the surgical scars（bad / moderate /good / very good）
Patients are rated whether they are satisfied with the surgical scars（bad / moderate /good / very good）
Time frame: 3 years
local tumor progress：Defined as the proportion of patients with active tumor at the edge of the treatment ：Defined as the proportion of patients with active tumor at the edge of the treatment
Defined as the proportion of patients with active tumor at the edge of the treatment area during follow-up after the tumor was completely treated
Time frame: 5 years
metastasis：Defined as the proportion of cases with metastasis from the beginning of the study to the end of the study or the death of the patient
Defined as the proportion of cases with metastasis from the beginning of the study to the end of the study or the death of the patient
Time frame: 5 years
complication：Defined as numbers of participants with side effect and major complications to the end of the study or the death of the patient
Defined as numbers of participants with side effect and major complications to the end of the study or the death of the patient
Time frame: 5 years
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