Impact of Netrin-1 in the Pathophysiology of Placenta Accreta Spectrum

Assiut University60 enrolled

Overview

The main goal of this study is to assess the role of Netrin 1, neogenin and ZEB1 in PAS-associated invasion

* To evaluate the immunohistochemical expression of these proteins in PAS specimens in comparison with the control placental tissues. * To correlate their expression with the demographic parameters. * To assess the correlation between their expression in PAS specimens.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Pathophysiology of Placenta Accreta

Interventions

no intervention appliedOTHER

no intervention applied

Eligibility

Sex: FEMALEMin age: 20 YearsMax age: 40 YearsHealthy volunteers:

Medical Language ↔ Plain English

inclusion criteria * PAS patients who underwent hysterectomy to allow proper pathologic grading of PAS exclusion criteria * patients with fundal and middle anterior or posterior placenta, * pregnancy associated with morbid conditions such as hypertension, diabetes mellitus, autoimmune disease, cardiac disease, renal disease, history of anemia, blood transfusion, other blood diseases and endocrinal disease; fetal distress or intrauterine growth retardation. * uterine scar pregnancies were excluded

Locations (1)

Hanaa Mohammed Mohammed Sayed

Asyut, Egypt

Outcomes

Primary Outcomes

impact of netrin-1 in the pathophysiology of placenta accreta spectrum

1. Evaluation of the immunohistochemical expression of netrin 1 in PAS specimens in comparison with the control placental tissues. 2. Evaluation of the immunohistochemical expression of neogenin in PAS specimens in comparison with the control placental tissues 3. Evaluation of the immunohistochemical expression of ZEB1 in PAS specimens in comparison with the control placental tissues. 4. Correlate their immunohistochemical expression with the demographic parameters and assess the correlation between their expression in PAS specimens.

Time frame: baseline

Data from ClinicalTrials.gov

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