To determine the value of NOX4, markers of mitochondria injury and function, and oxidative stress as real-time biomarkers to assess disease severity in patients with early autosomal dominant polycystic kidney disease (ADPKD).
This will be a cross sectional study and will include male and female, young (15-40-years) well characterized patients with early (eGFR\>70mL/min/1.73m2) ADPKD. Patients with different classes of disease severity will be selected using the ADPKD imaging classification. The study will include 60 class-1 (A-E) patients (N=12 per each sub-class).
Study Type
OBSERVATIONAL
Enrollment
60
Mayo Clinic
Rochester, Minnesota, United States
RECRUITINGNOX4 levels
Determination of NOX4 levels from urine and plasma samples
Time frame: Baseline
mtDNA copy number
Determination of mtDNA copy number from urine and plasma samples
Time frame: Baseline
Tricarboxylic Acid (TCA) cycle metabolites
Determination of TCA cycle metabolite concentration from urine and plasma samples
Time frame: Baseline
REDOX status
Determination of REDOX from urine and plasma samples
Time frame: Baseline
Total kidney volume (TKV)
Determined by MRI
Time frame: Baseline
Estimated Glomerular Filtration Rate (eGFR)
Estimated by CKD-epi equation
Time frame: Baseline
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