AcoArt sICAS: DCB in the Treatment of Symptomatic Intracranial Atherosclerotic Stenosis

Inclusion Criteria: * 18 to 80 years of age; * Patients with symptomatic intracranial atherosclerotic stenosis; * Patients with intracranial arterial de novo stenosis confirmed by digital subtraction angiography (DSA); * Confirmed by DSA，the diameter of the target vessel is between 2.5mm-4.5mm ; according to WASID method, the degree of stenosis of the target lesion is 70%-99%; * Baseline mRS score ≤2; * Voluntarily participate in this study and sign the informed consent form. Exclusion Criteria: * Patients with stroke within 2 weeks before procedure; * Patients with stroke caused by perforating artery occlusion; * Any history of brain parenchymal or other intracranial subarachnoid, subdural or extradural hemorrhage in the past 30 days; * Those who have received thrombolysis within 24 hours before procedure; * Deterioration of neurological function within 24 hours before procedure (defined as NIHSS score increased by ≥ 4 points over the baseline); * The vascular path showed in angiography is so tortuous that it is difficult to advance catheters to the target lesion or retrieve; * Lesions that investigators believe are not suitable for stenting; * Patients with thrombus in target vessel; * In addition to the target lesion, there are still other de novo lesion or ISR lesion with more than 70% diameter stenosis in intracranial arteries that need to be treated at the same time; * After endovascular treatment of the target lesion, there is still a stenosis of more than 50% in the main blood supplying artery or an obstructive lesion in the distal vessel of target lesion; * Major surgery (including open femoral artery, aortic or carotid artery surgery) within the past 30 days or planned within 90 days; * Patients with renal artery, iliac artery, and coronary artery requiring simultaneous intervention; * Combined with intracranial tumor, aneurysm or intracranial arteriovenous malformation; * Intracranial artery stenosis caused by non-atherosclerotic lesions, including: arterial dissection, moya-moya disease, vasculitis disease, herpes zoster, varicella-zoster or other viral vascular diseases, neurosyphilis, any Other intracranial infections, any intracranial stenosis related to cerebrospinal fluid cells, radiation-induced vascular disease, fibromuscular dysplasia, sickle cell disease, neurofibromatosis, central nervous system benign vascular disease, postpartum vascular disease, suspected Vasospasm, suspicious embolism recanalization, etc.; * Cardiac stroke or potential cardiogenic thromboembolism, with any of the following cardiogenic embolism causes: chronic or paroxysmal atrial fibrillation, mitral valve stenosis, mechanical valves, endocarditis, intracardiac thrombus or implant, dilated cardiomyopathy, spontaneous acoustic imaging of the left atrium; * Patients with myocardial infarction within 6 weeks before procedure; * Those who cannot tolerate general anesthesia due to insufficiency of important organs such as heart and lungs; * Patients with known severe hepatic and renal dysfunction; * Patients with hemoglobin\<100g/L, platelet count\<100×1,000,000,000/L, INR\>1.5 or there are uncorrectable factors leading to bleeding(if there are multiple checks, the last one shall prevail); * Patients who cannot receive dual antiplatelet therapy due to existing diseases or are tolerant to dual antiplatelet therapy confirmed by relevant test; * Patients with known severe allergies or contraindications to heparin, paclitaxel, contrast agents and other related intravascular treatment drugs; * Current alcohol or drug abuse, uncontrolled severe hypertension (systolic blood pressure\>180mmHg or diastolic blood pressure\>110mmHg); * Life expectancy \<1 year; * Pregnant or lactating women; * Patients who cannot complete the follow-up due to cognitive, emotional or mental illness; * Patients who are participating in other drug/device clinical trials and have not completed all follow-ups required by the programmer; * According to the judgement of the investigator, other situations that are not suitable for enrollment.