This study intends to adopt the method of multi-center prospective randomized controlled study. The aim of this study is to obtain localized excision values through a preeclampsia screening model established in early pregnancy, and to evaluate the efficacy of low-dose aspirin intervention for preeclampsia prevention in pregnant women at high risk of screening.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
TRIPLE
Enrollment
1,500
With the result of risk assessment for high risk and the risk of pregnant women, with each research center stratified random aspirin drug intervention, for each center screening high-risk and accord with the standard drug intervention study phase into eliminate pregnant women by using stochastic indicator 1:1 randomly into low-dose aspirin to prevent group and observation group, for each center in screening for risk and comply with the drug intervention study phase into the exclusion standard 1:1 by random indicator method pregnant women randomly into low-dose aspirin to prevent group and observation group.
the rate of preeclampsia
Hypertensive onset after 20 weeks of gestation is accompanied by proteinuria,or with thrombocytopenia, impaired liver function, renal insufficiency,pulmonary edema,headache without other explanation and so on.
Time frame: through study completion, an average of 1 year
the rate of hypertensive disorder during pregnancy
gestational hypertension, preeclampsia, chronic hypertension with preeclampsia, eclampsia, HELLP syndrome
Time frame: through study completion, an average of 1 year
the rate of placenta abruption
After 20 weeks of pregnancy, the placenta in its normal position is completely or partially removed from the uterine wall before delivery of the fetus
Time frame: through study completion, an average of 1 year
the rate of fetal growth restriction
The birth weight of the fetus is below two standard deviations of the average weight for the same gestational age or below the 10th percentile of normal weight for the same age
Time frame: through study completion, an average of 1 year
the rate of postpartum hemorrhage
Within 24 hours after the delivery of the fetus, the bleeding volume of vaginal delivery ≥500ml, cesarean delivery ≥1000ml
Time frame: within 24 hours after the delivery
the time and type of delivery
gestational week, vaginal delivery and cesarean section
Time frame: within 24 hours after the delivery
birth weight of newborn
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macrosomia, normal weight, low birth weight
Time frame: delivery time
Apgar score for newborns
≥8；4-7,；≤3
Time frame: delivery time
the rate of Neonatal NICU occupancy rate
the day of NICU occupancy
Time frame: through study completion, an average of 1 year