Negative Pressure Applied by the Equinox MPD for Severe Open Angle Glaucoma

Inclusion Criteria: 1. Male or female subjects ≥ 22 years of age at the time of signing the informed consent 2. Subjects willing to sign the informed consent and capable of committing to the study assessments 3. Subjects with orbital anatomy that permits a proper seal in both eyes when goggles are placed over eyes and can obtain IOP measurements with Excursion goggles in place 4. Subjects with a diagnosis of severe open-angle glaucoma (OAG definition is inclusive of primary open angle glaucoma, normal tension glaucoma, pseudoexfoliative glaucoma, and pigmentary glaucoma) in at least one eye, defined by glaucomatous optic disc or RNFL abnormalities AND visual field abnormalities in both hemifields and/or loss within 5 degrees of fixation in at least one hemifield as tested with standard automated perimetry (the diagnosis of the contralateral eye may include suspected OAG\< as well as mild/moderate/severe OAG) 5. Subjects with treatment regimens including current ocular hypotensive medications, prior non-incisional surgical procedures (e.g. MIGS and SLT), or any combination of the two 6. Subjects who are literate, able to speak English or Spanish, and able to understand and follow study instructions Exclusion Criteria: 1. Subjects with a history of allergy to primary study device material (i.e., silicone and latex) 2. Subjects with a history of any ocular disorder or condition (e.g., corneal transplant) in either eye that would likely interfere with the interpretation of the study results or compromise subject safety 3. Subjects with a history of retinal tear/detachment, wet macular degeneration, diabetic macular edema, or proliferative diabetic retinopathy 4. Subjects with active conjunctival chemosis or anterior uveitis 5. Subjects with a Van Herick grade of 2 or less. 6. Subjects with a history of prior incisional filtering (i.e. trabeculectomy) or tube/shunt glaucoma surgery in either eye 7. Subjects with best corrected visual acuity of 20/200 or worse in either eye due to glaucoma 8. Subjects who do not wish to or cannot comply with study procedures