Antibody Response in Hemodialysis and Non-dialysis Patients Diagnosed With COVID-19.

Saint Petersburg State University, Russia51 enrolled

Overview

This is prospective cohort study aimed to compare antibody response against SARS-CoV-2 in dialysis patients and non-dialysis-dependent volunteers. The research hypothesis is that dynamic of IgG antibodies against SARS-CoV-2 will differ in two groups. To determine whether there is a statistically significant interaction between factors "group" and "time" on the titer of IgG antibodies against SARS-CoV-2, a two-way repeated measures ANOVA will be used.

In both groups level of IgG antibodies against SARS-CoV-2 will be measured at the Day 1 (10 weeks from the date of first symptoms), Weeks 8 and 16 from the Day 1.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Dialysis Covid19

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Age 18 years or older * SARS-CoV-2 infection within 10 weeks prior enrollment, confirmed by PCR or strongly suspected on computed tomography * Providing informed consent Exclusion Criteria: * Refusal to provide informed consent

Locations (1)

Saint-Petersburg State University Hospital

Saint Petersburg, Russia

Outcomes

Primary Outcomes

Anti-SARS-COV-2 IgG level

Time frame: 16 weeks

Secondary Outcomes

Proportion of people with detectable Anti-SARS-COV-2 IgG in study groups

Time frame: Day 1, weeks 8, 16

Anti-SARS-COV-2 IgG level

Time frame: 8 weeks

Data from ClinicalTrials.gov

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