Transcranial Direct Current Stimulation in Post-stroke Fatigue

University College, London33 enrolled

Overview

This is a double-blind, sham-controlled, anodal tDCS study to understand the effect of increasing motor cortex excitability on post-stroke fatigue.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

TRIPLE

Enrollment

Conditions

Fatigue Stroke

Interventions

Anodal tDCSDEVICE

40 minutes of 2mA intensity direct current stimulation was delivered over both the right and left motor cortex simultaneously

sham tDCSDEVICE

The stimulator was switched off after 2 minutes of stimulation.

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: Diagnosed with stroke at least 3 months post-stroke Exclusion Criteria: Other neurological conditions on Anti-depressants severe motor impairment (affected hand grip \<60% unaffected hand) severe cognitive impairment (unable to follow instructions, or give informed consent) scored \>11 in the depression sub-section of HADS questionnaire contraindications for TMS or tES

Locations (1)

33 Queen Square, Institute of Neurology, UCL

London, United Kingdom

Outcomes

Primary Outcomes

Fatigue Severity Scale - 7

a questionnaire based fatigue scale

Time frame: 2 weeks

Secondary Outcomes

Resting Motor Threshold

This is a measure of cortical excitability as measured by transcranial magnetic stimulation

Time frame: 1 day

Input-output curves

This is a measure of cortical recruitment as measured by transcranial magnetic stimulation

Time frame: 1 day

Perceived effort - Explicit

A VAS scale associated with a grip task

Time frame: 1 day

Perceived effort - Implicit

A novel line length estimation task

Time frame: 1 day

Data from ClinicalTrials.gov

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