The "Bialystok Exercise Study in Diabetes" (BESD), is an exercise intervention study, conducted by the Department of Endocrinology, Diabetology and Internal Medicine and Clinical Research Centre of the Medical University of Bialystok. In the project, sedentary males at different stages of dysglycemia living in the city of Bialystok participate in three months of an exercise intervention consisting of supervised training sessions at a local fitness centre. The aim of the study is to assess the effectiveness of the exercise intervention in patients at different stages of dysglycemia progression, including type 2 diabetes and prediabetes and compare the response between groups.
Study Type
INTERVENTIONAL
Allocation
NON_RANDOMIZED
Purpose
PREVENTION
Masking
NONE
Enrollment
300
Supervised exercise intervention composed of mixed aerobic and strength activities, with the frequency of 3 sessions per week for 12 weeks, for a total number of trainings of 36.
Clinical Research Centre, Medical University of Bialystok
Bialystok, Podlaskie Voivodeship, Poland
HbA1c
Haemoglobin A1c measured by the high-performance liquid chromatography (HPLC) method
Time frame: Three months
Fasting glucose
Fasting glucose concentration measured in plasma using the colorimetric method
Time frame: Three months
2-hour glucose
Glucose concentration at 2-hour of the oral glucose tolerance test, measured in plasma using the colorimetric method
Time frame: Three months
Fasting insulin
Fasting insulin concentration measured in plasma using the immunoradiometric assay (IRMA)
Time frame: Three months
Lean body mass
Total lean body mass measured using the whole-body dual-energy X-ray absorptiometry (DXA)
Time frame: Three months
Fat mass
Total body fat mass measured using the whole-body dual-energy X-ray absorptiometry (DXA)
Time frame: Three months
Visceral Adipose Tissue mass
Visceral adipose tissue mass measured using the whole-body dual-energy X-ray absorptiometry (DXA)
Time frame: Three months
Weight
Total body weight measured using standardized scale
Time frame: Three months
HOMA-IR
Homeostatic model assessment for insulin resistance
Time frame: Three months
HOMA-beta
Homeostatic model assessment of beta cell function
Time frame: Three months
VO2max
Maximal oxygen consumption measured during cardio-pulmonary exercise test on treadmill
Time frame: Three months
Triglycerides (TG)
Serum triglycerides concentration measured using colorimetric method
Time frame: Three months
High-density lipoprotein cholesterol (HDL)
Serum high-density lipoprotein cholesterol (HDL) concentration measured using colorimetric method
Time frame: Three months
Low-density lipoprotein cholesterol (LDL)
Serum low-density lipoprotein cholesterol (LDL) concentration measured using colorimetric method
Time frame: Three months
Total cholesterol
Serum total cholesterol concentration measured using colorimetric method
Time frame: Three months
Plasma metabolome
Changes in plasma metabolites concentrations measured using untargeted metabolomics
Time frame: Three months
Skeletal muscle metabolome
Changes in skeletal muscle metabolites concentrations measured using untargeted metabolomics
Time frame: Three months
Subcutaneous adipose tissue metabolome
Changes in subcutaneous adipose tissue metabolites concentrations measured using untargeted metabolomics
Time frame: Three months
Skeletal muscle transcriptome
Changes in skeletal muscle gene and smallRNA expressions measured using untargeted transcriptomics
Time frame: Three months
Subcutaneous adipose tissue transcriptome
Changes in subcutaneous adipose tissue gene and smallRNA expressions measured using untargeted transcriptomics
Time frame: Three months
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