Steroid Sparing Treatment With in Newly Diagnosed Transplant Ineligible Patients With Multiple Myeloma

Inclusion Criteria: * Diagnosis of multiple myeloma with diagnosis * Must not have received previous therapy for multiple myeloma * Newly diagnosed and not considered candidate for high-dose chemotherapy * Adequate organ system function * A performance status ≤ 3 * Ability to swallow and retain oral medication * Female subjects of child bearing potential must be surgically sterile, be post-menopausal Exclusion Criteria: * A diagnosis of primary amyloidosis; monoclonal gammopathy of undetermined significance, smoldering multiple myeloma; non-secretory myeloma * A diagnosis of Waldenström's disease * Receiving cancer therapy * Radiation therapy within 14 days of enrollment * Major surgery within 2 weeks before enrollment * Human immunodeficiency virus -infected patients must be on effective anti-retroviral therapy with undetectable viral load within the past 6 months * Seropositive for hepatitis B, or seropositive for hepatitis C * Ongoing systemic bacterial, fungal or viral infection * Severe and/or uncontrolled medical conditions * Malignancy within 2 years of study enrollment * Women who are pregnant or lactating * Contraindications to required prophylaxis for deep vein thrombosis and pulmonary embolism.