Effects of a Personalized Diet on Cardiometabolic, Microbiome and Metabolomics Profiles in Minority Young Adults

University of Missouri-Columbia112 enrolled

Overview

The proposed study has two primary objectives i.e. to examine how improvements in diet quality via a personalized dietary intervention 1) benefit cardiometabolic outcomes in young Black adults differentially compared to non-Hispanic White adults, and 2) improve carbohydrate and lipid metabolism in relation to the gut microbiome.

The study is an 8-wk randomized, controlled, parallel arm clinical trial in which participants (age: 18-35 years, BMI: 25-45 kg/m2, race/ethnicity: Black or White) will be block randomized to a personalized dietary intervention or to receive conventional dietary advice. Outcomes assessed will include metabolites involved in carbohydrate and lipid regulation, gut microbiome composition, and cardiometabolic biomarkers.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

SINGLE

Enrollment

112

Conditions

Diet Intervention

Interventions

Personalized dietOTHER

Participants in this group will receive tailored nutrition counseling from a dietitian. To facilitate meeting these dietary goals, participants will be provided with nuts, fruits, and vegetables.

Conventional dietary adviceOTHER

Participants in the CD group will receive non-personalized, conventional dietary advice by a dietitian based on the MyPlate guidelines.

Eligibility

Sex: ALLMin age: 18 YearsMax age: 35 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion criteria: * Age: 18-35 years of age * BMI: 25-45 kg/m2 * Black including those of Hispanic ethnicity, and Non-Hispanic White individuals * Willingness to consume nuts, fruits and vegetables * Willing to comply with study protocol * Consistent diet and activity patterns for 4 weeks * Weight stable (≤5 kg change over the last 3 months) (Self-reported) * Non-smoker \>1 year or more Exclusion Criteria: * Allergies to fruits, vegetables, and nuts provided in the study * Illicit drug use * Recent start of medications that affect metabolism or appetite * Antibiotics * Coronary artery disease, peripheral artery disease, congestive heart failure, or dyslipidemia requiring drug therapy * Uncontrolled hypertension and blood pressure ≥ 180/110 Diabetes * Gastrointestinal disease and/or bariatric surgery * HIV positivity * Pregnant or lactating individuals

Locations (1)

University of Missouri-Columbia

Columbia, Missouri, United States