This study recruits 30 subjects into three groups, including two experimental groups and one control group. The two experimental groups receive acupuncture treatment for 4 weeks and two times functional magnetic resonance imaging scans as well as clinical symptom assessments. The control group receive one scan without any intervention. The aim of this study is to find the whether the effect of acupuncture treatment have diversity among migraineurs with different disease course.
This study recruits 10 patients with long course (\> 5 years) without aura migraine, 10 patients with short course (\< 5 years) without aura migraine and 10 healthy volunteers who meet the inclusion and exclusion criteria. Among the study, two migraine patient groups receive acupuncture treatment for 4 weeks, the frequency is 30 minutes each time, three times a week. According to the national standard of the people's Republic of China (GB / T 12346-2006) acupoint name and location, the acupuncture treatment includes SJ23 (Si Zhu Kong, unilateral), GB8 (Shuai Gu, unilateral), EX-HN5 (Tai Yang, unilateral), GB20 (Feng Chi, unilateral), LI4 (He Gu, bilateral), GB41 (Zu Lin Qi, bilateral), GB34 (Yang Ling Quan, bilateral) and SJ5 (Wai Guan, bilateral) acupoints. Both migraine patients receive scan in functional magnetic resonance imaging (Siemens 3.0T superconducting magnetic resonance scanner, Germany) and symptom scale assessment before the first acupuncture stimulation and post the last acupuncture stimulation. Healthy volunteers receive only one scanning without intervention.
Study Type
INTERVENTIONAL
Allocation
NON_RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
TRIPLE
Enrollment
30
The intervention is about acupuncture treatment, which has 4 weeks acupoint stimulation and the frequency is 30 minutes each times for 3 times per week. The acupoints include SJ23 (Si Zhu Kong, unilateral), GB8 (Shuai Gu, unilateral), EX-HN5 (Tai Yang, unilateral), GB20 (Feng Chi, unilateral), LI4 (He Gu, bilateral), GB41 (Zu Lin Qi, bilateral), GB34 (Yang Ling Quan, bilateral) and SJ5 (Wai Guan, bilateral).
Dongzhimen Hospital
Beijing, China
Headache Intensity
The headache intensity is measured by the value of Visual Analogue Scale which limits 1 to 10. The higher value of this scale represents the worse headache.
Time frame: Change from Visual Analogue Scale at 1 months.
Headache Days
The days when headache attacked. The increased day represents the worse headache.
Time frame: Change from the number of day at 1 months.
Headache Frequency
The maximum times in one day during the headache attacked. The increased time represents the worse headache.
Time frame: Change from the times of headache attack at 1 months.
Dataset of functional magnetic resonance imaging on brain
Dataset of functional magnetic resonance imaging on brain includes functional images, structural images and diffusion tensor images.
Time frame: Changes from the dataset of subject's brain area at 1 months.
Pittsburgh Sleep Quality Index
One of the clinical measurement. The higher value represents the worse quality of sleep.
Time frame: Change from the value of Pittsburgh Sleep Quality Index at 1 months.
Medical Outcomes Study Short-Form 36 questionnaire
One of the clinical measurement. The value range is 0 to 10, the higher value represents the better quality of life.
Time frame: Change from the value of Medical Outcomes Study Short-Form 36 questionnaire at 1 months.
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