A total of 74 Adult Patients with type 2 diabetes mellitus (T2D) will be enrolled and randomized into 2 groups. The intervention group will receive oral magnesium (Mg) supplementation. The study objectives are: 1. To estimate level of Mg (total and ionized) in patient with type 2 DM. 2. To determine the effect of Mg supplementation for diabetic patient on serum Mg level, glycemic control and level of inflammation. 3. To assess the correlation between serum Mg level and glycemic control and level of inflammatory mediators (CRP)
A total of 74 Adult Patients of both genders who had been diagnosed with T2D and are on oral anti-hyperglycemic drug and their HbA1C between 7and 8 %, will be enrolled in the study. Initially the study protocol will be explained \& informed written consent will be obtained from all participants. All subjects will be evaluated to ensure that they meet the eligibility criteria through: Full history taking, complete physical examination and investigations. the intervention group will receive oral magnesium (Mg) supplementation for 3 months (250 mg of elemental magnesium daily). The primary outcome is to determine the effect of Mg supplementation for diabetic patient on serum Mg level, glycemic control and level of inflammation.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Enrollment
80
250 mg of elemental magnesium daily for three months
Health education, oral antihyperglycemic medications according to American Diabetes Association (ADA) guidelines
Mokattam primary health care unit
Cairo, Mokattam, Egypt
Glycemic control
To determine the effect of oral Mg supplementation for diabetic patient on Glycemic control
Time frame: 3 months
Inflammation
To determine the effect of oral Mg supplementation for diabetic patient on inflammation (CRP)
Time frame: 3 months
Serum magnesium level
To determine the effect of Mg supplementation for diabetic patient on serum Mg level
Time frame: 3 months
Prevalence of hypomagnesemia
To estimate prevalence of hypomagnesemia in patients with type 2 DM.
Time frame: up to 4 weeks
Correlation of serum Mg level
To assess the correlation between serum Mg level and glycemic control and level of inflammatory mediators (CRP).
Time frame: up to 4 weeks
Total or ionized Mg
Determine the more accurate measure for Mg in diabetic patient either total or ionized Mg
Time frame: 3 months
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