2.1. Study Objectives * Primary Objective(s) * Identify the incidence and risk of CDI within one year after kidney, liver, and/or pancreas transplant * Secondary Objective(s) * Identify the risk factors for recurrent CDI post-transplant in patients who were diagnosed with a CDI within one year prior to Solid Organ Transplant * Evaluate the impact of CDI on graft survival following Solid Organ Transplant
* Single center, retrospective cohort chart review study design * Data will be collected on all liver, kidney, pancreas and combined transplant recipients who received their graft(s) from April 1, 2015 to July 31, 2018 * Will analyze outcomes from April 1, 2014 to July 31, 2019 * Patient list will be generated in Epic and Meditech * All data will be obtained from Epic and Meditech * All data will be collected retrospectively after the patient is discharged from the hospital
Study Type
OBSERVATIONAL
Enrollment
585
Data will be collected on all liver, kidney, pancreas and combined transplant recipients who received their graft(s) from April 1, 2015 to July 31, 2018
Jessica Rago
Dallas, Texas, United States
Incidence of C. Difficile infection (CDI) within one year post-transplant
Incidence of C. Difficile infection within one year post-transplant for CDI post-transplant.
Time frame: April 1, 2014 to July 31, 2019
Risk factors for CDI post-transplant - No.1
Risk factors transplanted organ
Time frame: April 1, 2014 to July 31, 2019
Risk factors for CDI post-transplant - No.2
Origin of transplanted graft including age of donor
Time frame: April 1, 2014 to July 31, 2019
Risk factors for CDI post-transplant No.-3
Induction agent used
Time frame: April 1, 2014 to July 31, 2019
Risk factors for CDI post-transplant No.4
Acid suppression
Time frame: April 1, 2014 to July 31, 2019
Risk factors for CDI post-transplant No.5
First time SOT recipient
Time frame: April 1, 2014 to July 31, 2019
Risk factors for CDI post-transplant No.6
History of CDI in the year prior to transplant
Time frame: April 1, 2014 to July 31, 2019
Risk factors for CDI post-transplant No.7
Co-infection with HIV/AIDS
Time frame: April 1, 2014 to July 31, 2019
Risk factors for CDI post-transplant No.8
Length of hospital stay
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Time frame: April 1, 2014 to July 31, 2019
Risk factors for CDI post-transplant No. 9
Length of intensive care unit stay
Time frame: April 1, 2014 to July 31, 2019
Risk factors for CDI post-transplant No.10
Intra-operative administration of blood products
Time frame: April 1, 2014 to July 31, 2019
Risk factors for CDI post-transplant No. 11
Antibiotic use in the 90 days prior to infection
Time frame: April 1, 2014 to July 31, 2019
Risk factors for CDI post-transplant No. 12
Antibiotic use in the 90 days post-transplant
Time frame: April 1, 2014 to July 31, 2019
Risk factors for CDI post-transplant No, 13
Hospitalization in the 90 days prior to transplantation
Time frame: April 1, 2014 to July 31, 2019
Risk factors for CDI post-transplant No, 14
Hospitalization in the 90 days post-transplant
Time frame: April 1, 2014 to July 31, 2019