This is an interventional, prospective and monocentric study. This study includes the evaluation before and after (neo)adjuvant therapy of : * one group of patients receiving anthracyclines and taxanes * a second group of patients receiving anthracyclines, taxanes and trastuzumab.
Study Type
INTERVENTIONAL
Allocation
NON_RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
NONE
Enrollment
13
before and after chemotherapy
before and after chemotherapy
Institut de Cancerologie Strasbourg Europe
Strasbourg, France
Change in vastus lateralis cross-sectional area
Measured from muscle microbiopsy sample
Time frame: Between Week 18 and 24 after chemotherapy
Alteration of patients body composition
Assessment using bio-impedance analysis
Time frame: Baseline (=before chemotherapy) and Between Week 18 and 24 (=after chemotherapy)
Alteration of patients strength
Assessment of maximal isometric muscle strength for knee extensors measured with force sensors.
Time frame: Baseline (=before chemotherapy) and Between Week 18 and 24 (=after chemotherapy)
Alteration of patients muscle architecture
Assessment using muscle ultrasonography
Time frame: Baseline (=before chemotherapy) and Between Week 18 and 24 (=after chemotherapy)
Alteration of patients quality of life
Self-assessment questionnaire Functional Assessment of Cancer Therapy - General (FACT-G) (version 3)
Time frame: Baseline (=before chemotherapy) and Between Week 18 and 24 (=after chemotherapy)
Evaluation of patient cachexia
Questionnaire Functional Assessment of Anorexia/Cachexia Therapy (FAACT) (version 4)
Time frame: Baseline (=before chemotherapy) and Between Week 18 and 24 (=after chemotherapy)
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