Effect of CPAP Therapy on Molecular Breath Patterns in Patients With OSA

Malcolm Kohler53 enrolled

Overview

Determination of changes in molecular breath patterns in OSA patients, naïve for OSA treatment before and after one month of CPAP therapy by untargeted, secondary electrospray ionisation-high resolution mass spectrometry (SESI-HRMS). Furthermore, breath patterns will be assessed for correlation and association to clinical outcomes such as change in OSA severity, sleepiness, and blood pressure.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Obstructive Sleep Apnea

Interventions

No interventionOTHER

No intervention

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Recently diagnosed OSA (AHI ≥20/h) * Patient is willing to start CPAP therapy * ESS \> 10 points * 18 years or above Exclusion Criteria: * Moribund or severe disease prohibiting protocol adherence * Use of oxygen therapy or home ventilation * Physical or intellectual impairment precluding informed consent or protocol adherence * Known malignancy, acute pulmonary disease, drug or alcohol abuse, known active inflammatory diseases (e.g. autoimmune disease), relevant congenital defects e.g. amino acid metabolism defect, relevant endocrinological disease, renal failure (GFR \< 15 mL/min) * Pregnant patients

Locations (1)

University Hospital Zurich

Zurich, Switzerland