Postbiotic MBS and Metformin Combination in Patients With T2DM

Inclusion Criteria: 1. Male or female subject who aged from 20 to 70. 2. BMI in between 18.5 and 35 kg/m2 inclusively. 3. Fasting blood sugar ≥ 126 mg/dL, and confirmed diagnosis of type-II diabetes. 4. 30 days prior to the screening visit (V1), HbA1c is steadily maintained in between 7-10% by medication. 5. Prior to the screening visit (V1), subjects have been regularly taken 500-200 mg/day for at least 90 days. Exclusion Criteria: 1. Pregnant or breastfeeding women or female subjects plan to enter pregnancy during study period. 2. Subjects who are allergic to soy or products containing it. 3. At investigator's discretion, subjects are unlikely to comply with study procedures due to a history of alcohol or drug addiction. 4. Subjects on vegetarian diet or other special diets (eg. Ketogenic or gluten-free diets). 5. Subjects have ongoing participation in another clinical trial that involves the use of investigational drugs, medical devices, dietary supplements, and/or cosmetics. 6. Subject with impaired renal function confirmed by Serum Total Bilirubin ≥ 1.5 upper limit of normal \[ULN\], Aspartate Transaminase/ Alanine Transaminase (AST/ALT) ≥ 2 ULN, Creatinine ≥ 2 ULN or eGFR \<60 mL/min/1.73 m\^2. 7. Subjects who have been diagnosed with malignant tumors within five (5) years before the screening visit (V1) with exception to subjects with topical cancer but show significant recovery following investigator's assessment, such as basal or squamous cell skin cancer, superficial bladder cancer, or prostate or cervix or carcinoma in situ of the breast. 8. 30 days prior to screening visit (V1), subjects have taken antibiotics, synthetic drugs (Sulfonamides, Fluoroquinolone, etc.), anti-fungal or anti-viral medication but not limited to topical forms for use in skin application. 9. Within 14 days prior to screening visit (V1), subjects have taken products or supplements that contain probiotics or prebiotics. 10. Within 14 days prior to screening visit (V1), subjects experience diarrhea caused by gastrointestinal infection (3 times of watery stool within 24 hours). 11. Within14 days prior to screening visit (V1), subjects have taken steroids, immunosuppressant, and/or inflammatory medicines. 12. Subjects took or intend to take medications other than metformin that may affect intestinal flora within 30 days prior to screening visit, during screening period or whole trial period. Examples of this kind of medication include DPP-4 inhibitors, GLP-1 receptor agonists, acarbose, hypoglycemic sulfonamides, thiazolidinediones, SGLT2 inhibitors, and insulin.