Cognitive dysfunction is one of the different consequences of excessive alcohol consumption, affecting many domains associated with prefrontal and temporal lobes, such as attention, verbal fluency, and memory. This study will explore the clinical impact of two cognitive rehabilitation tools to promote cognitive improvements of AUD individuals.
Excessive consumption of alcohol affects many functions associated with the prefrontal and temporal lobes, including different executive functions, memory, and complex motor control. Among several treatments, the Transtheoretical Model, a multidisciplinary approach, is one of the most standardized. However, it lacks effective and innovative cognitive rehabilitation tools. In this study, two cognitive rehabilitation tools, already clinically validated for stroke patients, will be implemented to promote cognitive recovery of Alcohol Use Disorder (AUD) individuals under treatment in the Alcoholic Rehabilitation Center S. Ricardo Pampuri from Casa de Saúde S. João de Deus (Madeira, Portugal). Within a randomized controlled trial with 60 participants, this study intend to assess and compare the clinical effectiveness of both a paper-and-pencil tasks training and content equivalent virtual reality (VR) simulation of activities of daily living with time-matched standard treatment.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
60
The Virtual Reality group will be involved in the Standard treatment protocol and will perform personalized activities of daily living in a virtual city environment (Reh@City).
The paper and Pencil group will be involved in the Standard treatment protocol and will perform personalized cognitive paper-and-pencil tasks, using the Task Generator tool.
The standard treatment protocol.
Instituto São João de Deus- CSSJD Funchal
Funchal, Portugal
Montreal Cognitive Assessment (Cognitive Screening).
Change from baseline in the Montreal Cognitive Assessment
Time frame: Baseline, Post-intervention (4 weeks), 6-month and 12-month follow-up
Frontal Assessment Battery (FAB- Executive functioning).
Change from baseline in the Frontal Assessment Battery.
Time frame: Baseline, Post-intervention (4 weeks), 6-month and 12-month follow-up
SF-36 Medical Outcomes Study 36 - Item Short - Form Health Survey
Change from baseline in the SF-36
Time frame: Baseline, Post-intervention (4 weeks), 6-month and 12-month follow-up
Toulouse-Pieron (Attention).
Change from baseline in the Toulouse-Pieron Cancellation Test.
Time frame: Baseline, Post-intervention (4 weeks), 6-month and 12-month follow-up
Verbal Paired Associates (WMS-III) (Memory).
Change from baseline in the Verbal Paired Associates (WMS-III)
Time frame: Baseline, Post-intervention (4 weeks), 6-month and 12-month follow-up
Rey Complex Figure (Visuospatial skills and visual memory).
Change from baseline in the Rey Complex Figure.
Time frame: Baseline, Post-intervention (4 weeks), 6-month and 12-month follow-up
Symbol Search and Coding (WAIS III).
Change from baseline in the Symbol Search and Coding (WAIS III)
Time frame: Baseline, Post-intervention (4 weeks), 6-month and 12-month follow-up]
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.
Letter-number sequencing (WAIS-III)- Working Memory
Change from baseline in the Letter-number sequencing (WAIS III)
Time frame: Baseline, Post-intervention (4 weeks), 6-month and 12-month follow-up]