Multi-centre prospective study evaluating computed tomography angiography studies performed for stroke patients as a diagnostic and prognostic imaging biomarker.
Diagnosis of coronavirus disease 2019 (COVID-19) relies on clinical features and reverse-transcriptase polymerase chain reaction (RT-PCR) testing. The latter is constrained by limited sensitivity and a timescale of hours to yield results, with no point-of-care test widely available. A dedicated computed tomography study of the chest is likely to be more sensitive than RT-PCR for COVID-19. Carotid computed tomography angiography (CTA) is a routine acute stroke investigation and includes the lung apices. We aim to assess the lung apices on CTA for ground glass opacification and compare this with COVID-19 RT-PCR test results and clinical outcome measures.
Study Type
OBSERVATIONAL
Enrollment
2,000
Royal United Hospitals Bath NHS Foundation Trust
Bath, United Kingdom
RECRUITINGNorth Bristol NHS Trust
Bristol, United Kingdom
RECRUITINGAccuracy of the computed tomography angiography biomarker relative to the COVID-19 RT-PCR test
Defined by sensitivity, specificity, positive and negative predictive values
Time frame: 1 month
Prognostic value of the computed tomography biomarker
Defined by its relationship with 30 day mortality and modified rankin scale following treatment
Time frame: 1 month
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.
University Hospitals Bristol NHS Foundation Trust
Bristol, United Kingdom
RECRUITINGFrimley Health NHS Foundation Trust
Camberley, United Kingdom
RECRUITINGCardiff and Vale University Health Board
Cardiff, United Kingdom
RECRUITINGUniversity Hospitals Coventry and Warwickshire NHS Trust
Coventry, United Kingdom
RECRUITINGLeeds Teaching Hospitals NHS Trust
Leeds, United Kingdom
RECRUITINGGuy's and St Thomas' NHS Foundation Trust
London, United Kingdom
RECRUITINGImperial College Healthcare NHS Foundation Trust
London, United Kingdom
RECRUITINGKing's College Hospital NHS FT (KCH)
London, United Kingdom
RECRUITING...and 2 more locations