Nitrates and IL-8 in Barrett's Esophagus

Mayo Clinic9 enrolled

Overview

The purpose of this study is to determine if nitrates and IL-8 (which are found in food and throughout the body regulating stomach acidity) play a role in Barrett's Esophagus and/or Esophageal Adenocarcinoma severity and if screening for these biomarkers can help predict patients that are more at risk for developing worsening disease.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Barrett Esophagus Esophageal Adenocarcinoma

Eligibility

Sex: ALLMin age: 18 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: \- Patients undergoing a clinicallly-indicated Esophagogastroduoedoscopy (EGD). Exclusion Criteria: * Comorbid inflammatory medical condition. * Use of antiinflammatory (aspirin and NSAIDs) or immunosuppressants over the past 1 week. * Use of nitrate containing medication in the past 1 week. * Consumption of nitrate rich foods in preceding 24 hours. * Known allergy to meat or nitrates

Locations (1)

Mayo Clinic in Rochester

Rochester, Minnesota, United States

Outcomes

Primary Outcomes

Nitrate Levels

Nitrate levels in serum, saliva and tissue in patients with normal squamous epithelium, erosive esophagitis, non-dysplastic BE (NDBE), and BE with high-grade dysplasia (HGD) or EAC

Time frame: Baseline

Serum and Tissue Biomarkers

Levels of IL-8 in patients diagnosed BE dysplasia and EAC

Time frame: Baseline

Secondary Outcomes

Biomarkers and disease progression

Level of IL-8 in serum and tissue in patients with NDBE that progressed to BE

Time frame: Baseline

Data from ClinicalTrials.gov

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