Nanocrystalline Hydroxyapatite Bone Substitute for Treating Periodontal Intrabony Defects

Weam Ahmed Elbattawy20 enrolled

Overview

The present clinical trial included 20 patients (11 females and 9 males, aged 36 to 56 years) suffering from moderate or advanced chronic periodontitis. Subjects were recruited from the outpatient clinic, Department of Oral Medicine and Periodontology, Faculty of Dentistry, Cairo University. This clinical trial was meant to assess clinically and radiographically the possible predictable results regarding the use of nanocrystalline hydroxyapatite bone graft substitute together with open flap debridement versus open flap debridement alone in the treatment of periodontal intrabony defects.

periodontal intrabony defects in patients with moderate or advanced chronic periodontitis were treated with open flap debridement only in the control group while open flap debridement and Nanocrystalline Hydroxyapatite bone graft substitute was performed for the intervention group. probing pocket depth, clinical attachment level, gingival index, plaque index, gingival recession and bone defect area were assessed at baseline and six months post surgically to evaluate the possible improvement in the clinical and radiographic outcomes.

Study Type

INTERVENTIONAL

Allocation

NON_RANDOMIZED

Purpose

TREATMENT

Masking

SINGLE

Enrollment

Conditions

Chronic Periodontitis

Interventions

open flap debridementPROCEDURE

open flap debridement for managing two and three walls intrabony periodontal defects

n-HA bone graftPROCEDURE

Nanocrystalline Hydroxyapatite bone graft substitute for managing two and three walls intrabony periodontal defects

Eligibility

Sex: ALLMin age: 35 YearsMax age: 56 Years

Medical Language ↔ Plain English

Inclusion Criteria: * systemically healthy patients * diagnosed with moderate to advanced chronic periodontitis * periodontal defects with at least one site with probing pocket depth (PPD) ≥ 5mm, clinical attachment loss (CAL) ≥ 4mm and two or three-walled intra-bony defects ≥ 3mm * evidence of intrabony defects using periapical radiographs Exclusion Criteria: * teeth with suprabony defects or 1-wall intrabony defects * pregnant or lactating women * patients taking any medication 3 months prior to the study * patients receiving any periodontal treatment 6 months prior to study initiation * former or current smokers.

Locations (1)

Cairo University

Cairo, Egypt

Outcomes

Primary Outcomes

change in probing pocket depth

William's graduated periodontal probe used to measure probing pocket depth from the gingival margin to the base of the sulcus

Time frame: baseline and after six months

Secondary Outcomes

change in clinical attachment level

William's graduated periodontal probe used to measure clinical attachment level from the cementoenamel junction to the base of the sulcus

Time frame: baseline and after six months

change in the bone defect area

periodical digital radiographs using Digora software to measure the bone defect area

Time frame: baseline and after six months

Data from ClinicalTrials.gov

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