Cardiac surgery has been described as altering endothelium structure and function, notably because of the use of cardiac-pulmonary bypass (CPB). Among the endothelial structure, glycocalyx, the thin layer recovering the endothelial surface, may be altered by the inflammatory process and probably the modification of flow during CPB. Endothelial and glycocalyx integrity are essential for vascular function and glycocalyx destruction is associated with organ failure and mortality. On the other hand, a chronic alteration of glycocalyx is observed in many diseases such as diabetes, hypertension or chronic kidney failure, all pathologies frequently observed in patients benefiting grom cardiac surgery. Thus the preoperative alteration of glycocalyx may be associated with postoperative organ failure.
Study Type
OBSERVATIONAL
Enrollment
600
Rouen University Hospital
Rouen, France
RECRUITINGassociation between preoperative sublingual glycocalyx thickness (glycocheck device) and major postoperative complications
occurence within 48 postoperative hours of at least one item among: * vasoplegic shock * cardiogenic shock * prolonged mechanical ventilation * acute kidney failure * Death
Time frame: 48 hours
association between preoperative sublingual glycocalyx thickness (glycocheck device) and death
death from any causes
Time frame: 28 days
association between preoperative sublingual glycocalyx thickness (glycocheck device) and cardiac arrythmia
atrial or ventricular arrythmia
Time frame: 28 days
association between preoperative sublingual glycocalyx thickness (glycocheck device) and Cerebral stroke
ischemic of hemorrhagic etiology
Time frame: 28 days
association between preoperative sublingual glycocalyx thickness (glycocheck device) and cognitive dysfunction
delirium or alteration of cognitive status
Time frame: 28 days
association between preoperative sublingual glycocalyx thickness (glycocheck device) and myocardial ischemia
occurence of ischemia: new Q wave, new occlusion of a coronary arteria, elevated troponinemia with a new dysfunction of at least one myocardial segment
Time frame: 28 days
association between preoperative sublingual glycocalyx thickness (glycocheck device) and acute respiratory failure
need for at least 5L/min of oxygen or non invasive ventilation of reintubation
Time frame: 28 days
association between preoperative sublingual glycocalyx thickness (glycocheck device) and sepsis
new sepsis condition as defined by SEPSIS-3 definition
Time frame: 28 days
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