Circulatory Coherence in COVID-19 and Non-COVID-19 Patients With Sepsis

University Hospital Hradec Kralove28 enrolled

Overview

This prospective observational pilot study investigates circulatory coherence in patients with COVID and non-COVID sepsis by comparison of microcirculation, endothelial glycocalyx, and clinical course

This prospective observational pilot study investigates circulatory coherence in patients with COVID and non-COVID sepsis by comparison of microcirculation (sublingual area video recordings and biochemical parameters of endothelial cells activation and damage) endothelial glycocalyx (sublingual area video recordings and biochemical parameter of glycocalyx degradation), and clinical course.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Viral Pneumonia Sepsis

Interventions

microcirculation recordingDIAGNOSTIC_TEST

non-invasive recording of sublingual microcirculation and blood sampling together with regular withdraws

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * adult * ICU admission due to sepsis with organ failure * need for organ support therapy (mechanical ventilation, CRRT, ECMO) * clinical and/or laboratory signs of circulatory instability Exclusion Criteria: * family withdrawal/disagreement * death within three days from ICU admission

Locations (1)

University Hospital Hradec Kralove

Hradec Králové, Třebeš, Czechia

Outcomes

Primary Outcomes

change in Proportion of Perfused Vessels (PPV) parameter

PPV describes microcirculation dysfunction

Time frame: 1st, 2nd and 3rd day

change in Syndecan-1 serum concentration

Syndecan-1 is a marker of endothelial glycocalyx

Time frame: 1st, 2nd and 3rd day

Secondary Outcomes

change in albuminuria

albuminuria is a marker of glomerular endothelial cells dysfunction

Time frame: 1st, 2nd and 3rd day

mortality in 28 days

mortality in 28 days from ICU admission

Time frame: 30 days

Data from ClinicalTrials.gov

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