Effect of Periodontal Treatment on the Biomechanical Properties of the Periodontium.

Inclusion Criteria: * Moderate/advanced/severe periodontitis * Intact anterior dentition upper yaw. * Expected performance of adequate oral hygiene * Subjects must have voluntarily signed the informed consent form before any study related procedures * Males and females with at least 18 years of age * Subjects must be committed to the study and the required follow-up visits * Subject must be judged in good general health as assessed by the investigator at time of non-surgical therapy Exclusion Criteria: * Any contraindications for subgingival instrumentation * Uncontrolled diabetes or other uncontrolled systemic diseases * Disorders or treatments that compromise wound healing * Medical conditions requiring chronic high dose steroid therapy * Bone metabolic diseases * Radiation or other immuno-oppressive therapy * Chronic anti-inflammatory treatment (≥3 times per week) within 4 weeks prior to treatment * Presence of oral lesions (such as ulceration, malignancy) * Mucosal diseases (e.g., lichen planus, mouth ulcer) * History of malignant disease in the oral cavity or previous radiotherapy to the head or neck * Treatment with an investigational drug or device within the 30 day period immediately prior to therapy on study day 0 * Female subjects who are nursing, pregnant, or plan to become pregnant * Antibiotic treatment