Remote Ischemic Preconditioning in Cardiac Surgery

Assiut University90 enrolled

Overview

Aim of the work : Evaluation of the role of Remote Ischemic Preconditioning (RIP) on liver function in patients undergoing on-pump cardiac surgery.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

DOUBLE

Enrollment

Conditions

Ischemia Reperfusion Injury

Interventions

remote ischemic preconditioningPROCEDURE

3 cycles of 5-minutes inflation of a blood pressure cuff to 200mmHg (or at least to a pressure 50mm Hg higher than the systolic arterial pressure) to one upper arm, followed by5-minutes reperfusion with the cuff deflated

Sham remote ischemic preconditioningPROCEDURE

3cycles of upper limb pseudo ischemia (low pressure, 5-minutes blood pressure cuff inflation to a pressure of 20 mm Hg and 5-minutes cuff deflation).

Eligibility

Sex: ALLMin age: 18 YearsMax age: 70 Years

Medical Language ↔ Plain English

Inclusion Criteria: 1. Being candidate for on-pump cardiac surgery. 2. Willing to participate in the study 3. Ages eligible for the study: 18 to 70 years. 4. Gender eligible for the study : both Exclusion Criteria: 1. Patient refusal. 2. Known cause of possible liver function disturbances that includes right heart failure, acute inflammation of gallbladder or any other complication of gallstone disease. 3. Active viral and non viral hepatitis. 4. Pregnant women. 5. History of peripheral nerve disease or peripheral vascular disease of the extremities

Locations (1)

Assiut University hospital

Asyut, Asyut Governorate, Egypt

RECRUITING

Outcomes

Primary Outcomes

liver function test

Direct Bilirubin

Time frame: 3 postoperative days

Data from ClinicalTrials.gov

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